Evidence map›Paper›PMID 40672297›Full record

ArticlebioRxiv : the preprint server for biology2025

Cortical and white matter T1w/T2w development proceed in concert during early infancy.

Stephanie Zika, Kelly Chang, Altan Orhon, John Kruper, Ariel Rokem, Mareike Grotheer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Stephanie ZikaDepartment of Psychology, Philipps-Universität Marburg, Schulstraße 12, 35037 Marburg, Germany.ORCID 0009-0009-8500-0635
Kelly ChangDepartment of Psychology, University of Washington, Seattle, WA 98105.ORCID 0000-0001-5385-2782
Altan OrhonDepartment of Psychology, University of Washington, Seattle, WA 98105.ORCID 0000-0002-4412-5580
John KruperDepartment of Psychology, University of Washington, Seattle, WA 98105.ORCID 0000-0003-0081-391X
Ariel RokemDepartment of Psychology, University of Washington, Seattle, WA 98105.ORCID 0000-0003-0679-1985
Mareike GrotheerDepartment of Psychology, Philipps-Universität Marburg, Schulstraße 12, 35037 Marburg, Germany.

Funding

CRCNS: Community-supported open-source software for computational neuroanatomyR01EB027585 · NIBIB · TRUSTEES OF INDIANA UNIVERSITY · PI Eleftherios Garyfallidis · 2018 to 2026
$2.6M
Visual Cortex as a Window to Microstructural and Functional Development of the Human BrainR01EY033835 · NEI · STANFORD UNIVERSITY · PI GRILL-SPECTOR, KALANIT, PAREDES, MERCEDES · 2022 to 2025
$2.4M
NIPreps: integrating neuroimaging preprocessing workflows across modalities, populations, and speciesRF1MH121867 · NIMH · STANFORD UNIVERSITY · PI POLDRACK, RUSSELL A, ROKEM, ARIEL SHALOM · 2021 to 2022
$1.6M
A data science toolbox for analysis of Human Connectome Project diffusion MRIRF1MH121868 · NIMH · UNIVERSITY OF WASHINGTON · PI ROKEM, ARIEL SHALOM · 2019 to 2019
$707k
NEI NIH HHS R01 EY033835NIBIB NIH HHS R01 EB027585NIMH NIH HHS RF1 MH121867NIMH NIH HHS RF1 MH121868
6 · The paper itself

Abstract

The infant brain undergoes rapid myelin growth that is critical for healthy brain function. This development has been characterized for gray and white matter independently, but the link between gray and white matter myelination remains unexplored. To close this knowledge gap, we processed large-scale (N=279) Developing Human Connectome Project data with automated software to identify 26 white matter bundles and map their cortical terminations, before evaluating T1w/T2w development in individuals. We found that mean T1w/T2w as well as the slope of T1w/T2w development are correlated across tissues. This synchrony of brain T1w/T2w is impacted by birth age and postnatal experience, whereas inter-individual differences in this synchrony predict motor outcomes at 17 - 25 months of age. As T1w/T2w is associated with myelin content, our results reveal an intricate relationship between gray and white matter myelination, highlighting the importance of conjointly evaluating both tissues.

Identifiers

PMID40672297
PMCPMC12265654

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.