ArticlebioRxiv : the preprint server for biology2025
Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response.
Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava, Markus Höpfler, Jiri Koubek, Günter Kramer, Fabian den Brave, Axel Mogk, David S Gross and 1 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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1 · What the graph read from itWhat it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors.
Carmen Ruger-HerrerosCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.ORCID 0000-0002-3982-9962 Lucia SvobodaCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.
Gurranna MaleDepartment of Biochemistry & Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA.
Aseem ShrivastavaCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.
Markus HöpflerCentre for Genomic Regulation (CRG), Genome Biology Programme, C/ Dr. Aiguader 88, 08003 Barcelona, Spain.
Jiri KoubekCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.ORCID 0000-0002-5117-6570 Günter KramerCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.ORCID 0000-0001-7552-8393 Fabian den BraveInstitut für Biochemie und Molekularbiologie, Universität Bonn, Nussallee 11, 53115 Bonn, Germany.
Axel MogkCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.ORCID 0000-0003-3674-5410 David S GrossDepartment of Biochemistry & Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA.ORCID 0000-0002-7957-8790 Bernd BukauCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.ORCID 0000-0003-0521-7199 Funding
Genome Architecture and Gene Control in Response to StressR01GM138988 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI GROSS, DAVID SAMUEL · 2020 to 2023
$1.2MNIGMS NIH HHS R01 GM138988
6 · The paper itselfAbstract
The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs).
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PMID40672285
PMCPMC12265559
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