Evidence map›Paper›PMID 40672285›Full record

ArticlebioRxiv : the preprint server for biology2025

Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response.

Carmen Ruger-Herreros, Lucia Svoboda, Gurranna Male, Aseem Shrivastava, Markus Höpfler, Jiri Koubek, Günter Kramer, Fabian den Brave, Axel Mogk, David S Gross and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Carmen Ruger-HerrerosCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.ORCID 0000-0002-3982-9962
Lucia SvobodaCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.
Gurranna MaleDepartment of Biochemistry & Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA.
Aseem ShrivastavaCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.
Markus HöpflerCentre for Genomic Regulation (CRG), Genome Biology Programme, C/ Dr. Aiguader 88, 08003 Barcelona, Spain.
Jiri KoubekCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.ORCID 0000-0002-5117-6570
Günter KramerCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.ORCID 0000-0001-7552-8393
Fabian den BraveInstitut für Biochemie und Molekularbiologie, Universität Bonn, Nussallee 11, 53115 Bonn, Germany.
Axel MogkCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.ORCID 0000-0003-3674-5410
David S GrossDepartment of Biochemistry & Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA.ORCID 0000-0002-7957-8790
Bernd BukauCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.ORCID 0000-0003-0521-7199

Funding

Genome Architecture and Gene Control in Response to StressR01GM138988 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI GROSS, DAVID SAMUEL · 2020 to 2023
$1.2M
NIGMS NIH HHS R01 GM138988
6 · The paper itself

Abstract

The heat shock response (HSR) is the major defense mechanism against proteotoxic stress in the cytosol and nucleus of eukaryotic cells. Initiation and attenuation of the response are mediated by stress-dependent regulation of heat shock transcription factors (HSFs).

Identifiers

PMID40672285
PMCPMC12265559

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.