Evidence map›Paper›PMID 40672227›Full record

ArticlebioRxiv : the preprint server for biology2025

HER2; p53 Co-mutated Cancers Show Increased Histone Acetylation and are Sensitive to Neratinib plus Trastuzumab Deruxtecan.

Xiaoqing Cheng, Jacob Hsia, Jesus Iraheta, Joanna Gongora, Maureen Highkin, Xiaohua Jin, Zhanfang Guo, Julie L Prior, John R Edwards, Shunqiang Li and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiaoqing ChengDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Jacob HsiaDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Jesus IrahetaDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Joanna GongoraDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110.
Maureen HighkinDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Xiaohua JinDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Zhanfang GuoDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Julie L PriorDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
John R EdwardsDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Shunqiang LiDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Ian S HagemannAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110.
Cynthia X MaDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Zongtao LinDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110.
Benjamin A GarciaDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110.
Ron BoseDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-1977-8894

Funding

Washington University PDX Development and Trial Center - Evaluation of Abemaciclib in Combination with Olaparib in Ovarian Cancer and Breast Cancer Patient-derived Xenograft ModelsU54CA224083 · NCI · WASHINGTON UNIVERSITY · PI Kian-Huat Lim · 2017 to 2026
$13.0M
IVIS Spectrum CT Preclinical In Vivo Imaging SystemS10OD027042 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2019 to 2019
$599k
Multispectral Optoacoustic Tomography (MSOT) SystemS10OD025264 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2018 to 2018
$544k
NCI NIH HHS U54 CA224083NIH HHS S10 OD025264NIH HHS S10 OD027042
6 · The paper itself

Abstract

In metastatic breast cancer,

Indexed as

Breast cancerhistone modificationneratinibp53 mutanttrastuzumab deruxtecan

Identifiers

PMID40672227
PMCPMC12265670

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.