Evidence map›Paper›PMID 40672218›Full record

ArticlebioRxiv : the preprint server for biology2025

Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity.

Nicolas Marzolini, Taylor V Brysgel, Ryan J Rahman, Eno-Obong Essien, Saw Y Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N Patel, Sachchidanand Tiwari, Carolann L Espy and 14 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Nicolas MarzoliniORCID 0000-0002-0658-8664
Saw Y Nwe
Aparajeeta Majumder
Sachchidanand TiwariORCID 0000-0003-1541-5092
Fengyi Dong
Vladimir V ShuvaevORCID 0000-0003-2449-460X
Oscar A Marcos-ContrerasORCID 0000-0002-1247-4882
Vladimir R MuzykantovORCID 0000-0001-6648-1204
Sahily Reyes-EstevesORCID 0000-0002-2139-522X

Funding

Institutional Clinical and Translational Science AwardKL2TR001879 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$13.7M
NCATS NIH HHS KL2 TR001879NINDS NIH HHS L70 NS134081
6 · The paper itself

Abstract

DNA-lipid nanoparticles (DNA-LNPs) loaded with inhibitors of the cGAS-STING pathway enable safe and effective delivery of DNA

Identifiers

PMID40672218
PMCPMC12265523

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.