Evidence map›Paper›PMID 40672203›Full record

ArticlebioRxiv : the preprint server for biology2025

ENHANCED CLEAVAGE OF GENOMIC

Christine A Hodge, Niles P Donegan, David A Armstrong, Mathew S Hayden, Alexandra L Howell

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Christine A HodgeDepartment of Dermatology, Dartmouth Health, Lebanon, NH, USA.
Niles P DoneganResearch Service, V.A. Medical Center, White River Junction, VT, USA.ORCID 0000-0002-8328-2044
David A ArmstrongDepartment of Dermatology, Dartmouth Health, Lebanon, NH, USA.ORCID 0000-0003-1748-2520
Mathew S HaydenDepartment of Dermatology, Dartmouth Health, Lebanon, NH, USA.ORCID 0000-0003-1670-6430
Alexandra L HowellResearch Service, V.A. Medical Center, White River Junction, VT, USA.ORCID 0000-0002-2362-2596

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
BLRD VA I01 BX005248NCI NIH HHS P30 CA023108
6 · The paper itself

Abstract

Development of novel CRISPR/Cas systems enhances opportunities for gene editing to treat infectious diseases, cancer, and genetic disorders. We evaluated CasX2 (

Indexed as

CasX2CCR5CRISPR/Casguide RNA

Identifiers

PMID40672203
PMCPMC12265720

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.