Evidence map›Paper›PMID 40672197›Full record

ArticlebioRxiv : the preprint server for biology2025

Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer.

Pooneh Koochaki, Biao Qiu, Jesse A Coker, Alexander Earsley, Nancy S Wang, Todd Romigh, Christopher M Goins, Shaun R Stauffer, Olga Boudker, Abhishek A Chakraborty

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Pooneh KoochakiDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Biao QiuDepartment of Physiology & Biophysics, Weill Cornell Medicine, New York, NY 10021.ORCID 0000-0003-3633-5091
Jesse A CokerCenter for Therapeutics Discovery, Cleveland Clinic, Cleveland, OH 44195.
Alexander EarsleyDepartment of Physiology & Biophysics, Weill Cornell Medicine, New York, NY 10021.
Nancy S WangCenter for Therapeutics Discovery, Cleveland Clinic, Cleveland, OH 44195.
Todd RomighCenter for Therapeutics Discovery, Cleveland Clinic, Cleveland, OH 44195.
Christopher M GoinsDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Shaun R StaufferCenter for Therapeutics Discovery, Cleveland Clinic, Cleveland, OH 44195.
Olga BoudkerDepartment of Physiology & Biophysics, Weill Cornell Medicine, New York, NY 10021.
Abhishek A ChakrabortyDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.

Funding

The structural dynamics of a glutamate transporter homologueR37NS085318 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BOUDKER, OLGA · 2014 to 2020
$4.3M
NINDS NIH HHS R37 NS085318
6 · The paper itself

Abstract

Renal Cell Carcinomas (RCCs) depend metabolically on the trimeric sodium-coupled aspartate and glutamate transporter, SLC1A1/EAAT3; however, pharmacologically targeting SLC1A1 is challenging. We determined a cryo-EM structure of human SLC1A1 bound to compound

Indexed as

cellular IC50cryo-EMdrug-resistant mutantsEAAT3impedance assaysin silico dockingmedicinal chemistrymetabolic regulationRCCSLC1A1thermal shift assays

Identifiers

PMID40672197
PMCPMC12265667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.