Evidence map›Paper›PMID 40672192›Full record

ArticlebioRxiv : the preprint server for biology2025

Navigating parasite antigen genetic diversity in the design of

Paolo Bareng, Kenneth W Wu, Eizo Takashima, Dionne Argyropoulos, Lauren Smith, Myo Naung, Ramin Mazhari, Kael Schoffer, Nicholas Kiernan-Walker, Anju Abraham and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Paolo BarengCentre for Innovation in Infectious Diseases and Immunology Research (CIIDIR), Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, Geelong, VIC, Australia.
Kenneth W WuWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Eizo TakashimaDivision of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Ehime, Japan.
Dionne ArgyropoulosWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Lauren SmithWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Myo NaungCentre for Innovation in Infectious Diseases and Immunology Research (CIIDIR), Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, Geelong, VIC, Australia.
Ramin MazhariWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Kael SchofferWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Nicholas Kiernan-WalkerWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Anju AbrahamWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Macie LamontWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Somya MehraLife Sciences Discipline, Burnet Institute, Melbourne, VIC, Australia.
Pailene LimWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Jetsumon SattabongkotMahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Wuelton MonteiroFundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.
Marcus LacerdaFundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.
Julie HealerWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Chetan E ChitnisUnité de Biologie de Plasmodium et Vaccins, Institut Pasteur, Université Paris Cité, 25-28 Rue du Dr Roux, 75015 Paris, France.
Wai-Hong ThamWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID 0000-0001-7950-8699
Takafumi TsuboiDivision of Cell-Free Sciences, Proteo-Science Center, Ehime University, Matsuyama, Ehime, Japan.
Ivo MuellerWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Alyssa E BarryCentre for Innovation in Infectious Diseases and Immunology Research (CIIDIR), Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, Geelong, VIC, Australia.ORCID 0000-0002-1189-2310
Rhea J LongleyWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

Funding

Discovery & validation of novel P. vivax antigens for identification and monitoriR01AI104822 · NIAID · MAHIDOL UNIVERSITY · PI PRACHUMSRI, JETSUMON · 2013 to 2017
$672k
NIAID NIH HHS R01 AI104822
6 · The paper itself

Abstract

Background: Methods: We analysed global Findings: Extensive genetic diversity was identified in two Interpretation: Even highly diverse antigens can be effective serological exposure markers. Our findings highlight the importance of testing the impact of genetic diversity when designing serological tests and suggest practical strategies, such as using a mix of antigens, to ensure consistent performance across regions.

Identifiers

PMID40672192
PMCPMC12265567

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.