Evidence map›Paper›PMID 40672089›Full record

ArticleJournal of gastrointestinal oncology2025

The diagnostic efficiency of tissue factor pathway inhibitor 2 methylation in the detection of colorectal cancer: a systematic review and meta-analysis.

Xiao-Ling Wang, Shuo Qin, Li Liu, Yu-Qi Jia, Ying Wang, Yu-Jie Zhou, Bruno Ramos-Molina, Manuel Valladares-Ayerbes, Moritz Eidens, Zhi-Zhen Liu

Abstract read
In one paragraph

Article in Journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiao-Ling WangDepartment of Clinical Laboratory, Shanxi Hospital of Traditional Chinese Medicine, Taiyuan, China.
Shuo QinAcademy of Medical Sciences, Shanxi Medical University, Taiyuan, China.
Li LiuDepartment of Clinical Laboratory, Shanxi Hospital of Traditional Chinese Medicine, Taiyuan, China.
Yu-Qi JiaDepartment of Clinical Laboratory, Shanxi Hospital of Traditional Chinese Medicine, Taiyuan, China.
Ying WangDepartment of Clinical Laboratory, Shanxi Hospital of Traditional Chinese Medicine, Taiyuan, China.
Yu-Jie ZhouDepartment of Clinical Laboratory, Shanxi Hospital of Traditional Chinese Medicine, Taiyuan, China.
Bruno Ramos-MolinaObesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain.
Manuel Valladares-AyerbesDepartment of Medical Oncology, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina (IBIS), Sevilla, Spain.
Moritz EidensMainz Biomed Germany GmbH, Mainz, Germany.
Zhi-Zhen LiuDepartment of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Colorectal cancer (CRC) is a common malignant tumor of the digestive tract. Screening of high risk populations and early diagnosis of CRC are of great importance. Tissue factor pathway inhibitor 2 ( Methods: A search strategy based on the Population, Intervention, Comparison, Outcomes and Study (PICOS) principle was employed to retrieve relevant literatures from the PubMed, Web of Science, and EMBASE databases focused on the diagnosis of CRC patients with Results: In total, 14 diagnostic test accuracy studies, comprising 3,330 subjects (1,983 CRC patients and 1,347 non-CRC controls), were included in the meta-analysis. The meta-analysis demonstrated a non-significant publication bias (P=0.29). Meta-regression further identified country, detection methodology, and sample type as significant contributors to heterogeneity. The combined sensitivity and specificity of Conclusions: Our findings showed that

Indexed as

Colorectal cancer (CRC)meta-analysismethylationtissue factor pathway inhibitor 2 (TFPI2)

Identifiers

PMID40672089
PMCPMC12260951

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.