ArticleJournal of gastrointestinal oncology2025
Log odds of positive lymph nodes-based staging system for colorectal cancer patients with inadequate lymph nodes harvested: a potential reference for adjuvant chemotherapy.
Article in Journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Nonlinear association between number of lymph nodes resected and survival in T1N0M0 colorectal cancer: a SEER-based analysis.Updates in surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The current tumor node metastasis (TNM) staging manual of the American Joint Committee on Cancer (AJCC) could not satisfactorily classify colorectal cancer (CRC) patients with lymph node examined (LNE) <12. This study aims to construct a novel staging system for better predicting cancer-specific survival (CSS) in this special population. Methods: Medical records of 4,170 CRC patients were retrospectively reviewed, including 3,927 cases from the Surveillance, Epidemiology, and End Results (SEER) database (development set) and 243 cases from The Second Affiliated Hospital of Harbin Medical University (validation set). Survival analysis was performed using Cox regression model. The best cutoff point of log odds of positive lymph nodes (LODDS) of CSS was calculated through the X-tile software. The performance of novel stage (nStage) was appraised by concordance index (C-index), receiver operating characteristic (ROC) curves and decision curve analyses (DCA). Results: LODDS was an independent prognosticator for CSS and a novel N stage (nN stage) was built subsequently (nN0: LODDS ≤-1.1, nN1: -1.1< LODDS ≤-0.2 or cancer nodule formation and nN2: LODDS >-0.2). The C-indexes in the nStage system were higher and the 5-year ROC curves and DCA showed the superior power of the model compared with the AJCC system. Besides, in nStage C-E but not A-B CRC, patients who were treated with adjuvant chemotherapy posed a better prognosis. Conclusions: The nStage system demonstrated superiority over the AJCC staging system for CRC patients with LNE <12. And the proposed nStage system might provide clinicians with a potential reference for selecting patients who might benefit from adjuvant chemotherapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.