ArticleCureus2025
Prognostic Value of Time-to-Positivity and Cycle Threshold (CT) Values in Predicting Tuberculosis Outcomes and Multidrug Resistance in Northern India: A Study Using Liquid Culture and Molecular Diagnostics.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundRelapse and default cases of pulmonary tuberculosis (PTB) present a significant challenge due to higher bacillary loads and the increased risk of developing multidrug-resistant tuberculosis (MDR-TB). Conventional diagnostic methods, such as smear microscopy, lack sensitivity and timeliness. This study evaluates the prognostic value of time to positivity (TTP) from liquid culture and cycle threshold (CT) values from GeneXpert
objectivesThis study aimed to assess the utility of baseline mycobacteria growth indicator tube (MGIT) TTP and GeneXpert CTvalues as early biomarkers for prognosis and the risk of MDR-TB development in smear-positive relapse and default PTB patients.
methodsThis cross-sectional study with a prospective arm enrolled 72 adult PTB patients (relapse, default, or treatment failure). Sputum samples underwent smear microscopy, MGIT liquid culture, and GeneXpert testing. Baseline and three-month follow-up results were compared. TTP and CT values were correlated with microbiological outcomes.
resultsMGIT culture was positive in 52.8% (38/72) of patients (mean TTP: 26.5 days). In comparison, GeneXpert detected
conclusionBaseline MGIT TTP demonstrates significant prognostic potential in identifying patients with PTB at risk of treatment failure or MDR development. In contrast, GeneXpert CT values, while useful diagnostically, were less predictive of outcomes. Incorporating TTP into routine clinical practice could enable earlier intervention and improve TB control strategies in high-burden settings.
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