ArticleCureus2025
Identifying Predictive Factors for Complete Skin Clearance at Week 52 by Deucravacitinib in Moderate-to-Severe Psoriasis: A Prospective Observational Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Deucravacitinib in dermatology: current indication and existing off-label data.Drugs in context · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeucravacitinib, an oral selective tyrosine kinase 2 inhibitor, is effective for moderate-to-severe psoriasis. However, not all patients can achieve complete skin clearance (CSC) by deucravacitinib even after long-term treatment (one year). Therefore, we sought to determine predictive baseline factors of achieving CSC (Psoriasis Area and Severity Index score 0) at week 52.
methodsIn this prospective single‑center study (December 2022 - February 2025), we enrolled 77 patients aged ≥ 15 years and treated them with deucravacitinib 6 mg once daily. Baseline demographic, clinical, and laboratory factors were compared between patients who achieved CSC at week 52 and those who did not.
resultsSeventy-seven patients aged ≥ 15 years with moderate to severe psoriasis received deucravacitinib 6 mg once daily, and 15 patients achieved CSC at week 52. We compared patients' background factors and baseline clinical and laboratory indices between week 52 CSC achievers and non-achievers. The age (years) of week 52 CSC achievers (median: 55.0; IQR: 45.0-65.5) was significantly younger compared to non-achievers (median: 67.0; IQR: 55.3-76.0) (p = 0.0461, by Mann-Whitney U test; area under the curve (AUC) = 0.667). Additionally, the body mass index (BMI) of week 52 CSC achievers (median: 20.9; IQR: 18.3-22.9) was significantly lower compared to non-achievers (median: 23.6; IQR: 22.0-27.1) (p = 0.00571, by Mann-Whitney U test; AUC = 0.733). Compared to non-achievers, week 52 CSC achievers showed higher and faster improvements of nail, scalp, and genital lesions and quality of life, evaluated by the Dermatology Life Quality Index.
conclusionsA BMI < 22.9 kg/m² and age < 61 years independently identify patients most likely to obtain CSC at week 52 with deucravacitinib. These cut‑offs can support early treatment selection and stratification in future prospective trials, facilitating personalized care for psoriasis.
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