Evidence map›Paper›PMID 40672006›Full record

ArticleCureus2025

Defying the Odds: Small Cell Lung Cancer with Essential Thrombocythemia and Secondary Cancers.

Mathew George, Thomas Mathew, Jonathon Vundum, Anita Mani, Israfil Baluwala

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mathew GeorgeMedcial Oncology, Calvary Mater, Newcastle, AUS.
Thomas MathewUniversity of Newcastle, School of Medicine and Public Health, Newcastle, AUS.
Jonathon VundumMedical Oncology, Calvary mater, Newcastle, AUS.
Anita ManiPathology, Tamworth Rural Referral Hospital, New South Wales, AUS.
Israfil BaluwalaHematology, Calvary Mater, Newcastle, AUS.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small cell lung cancer (SCLC) is an aggressive malignancy with historically poor survival outcomes, especially in patients with significant comorbidities. This report presents a rare case of a 65-year-old woman with limited-stage SCLC and JAK2-positive essential thrombocythemia (ET), who subsequently developed multiple malignancies including papillary thyroid carcinoma, right-sided colon adenocarcinoma, and basal cell carcinoma. Despite serious complications such as subdural hematoma and intra-abdominal bleeding, the patient remains clinically stable over a decade after her initial diagnosis. Genetic testing revealed no hereditary cancer syndromes, suggesting a potential role of chronic inflammation and prior therapies in her cancer trajectory. This case underscores the importance of early aggressive therapy, vigilant long-term follow-up, and multidisciplinary coordination in managing complex oncologic and hematologic conditions.

Indexed as

essential thrombocythemiajak2 mutationmyeloproliferative neoplasmsecondary malignanciessmall cell lung cancer

Identifiers

PMID40672006
PMCPMC12264305

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.