Evidence map›Paper›PMID 40671928›Full record

ArticleSmart molecules : open access2025

Complex-mediated nucleophilic aromatic substitution with aryl nitriles to realize intramolecular flapping-restricted D-A AIEgens for bioimaging.

Feng Liu, Junkai Liu, Junyi Gong, Runfeng Lin, Siyuan Qiu, Zicheng Liu, Chongyang Li, Miao Meng, Shijie Li, Mei Tu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Smart molecules : open access, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Feng LiuCollege of Chemistry and Materials Science Jinan University Guangzhou China.
Junkai LiuDepartment of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and Technology Kowloon Hong Kong China.
Junyi GongSchool of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong, Shenzhen (CUHK-SZ) Shenzhen Guangdong China.
Runfeng LinCollege of Chemistry and Materials Science Jinan University Guangzhou China.
Siyuan QiuCollege of Chemistry and Materials Science Jinan University Guangzhou China.
Zicheng LiuCollege of Chemistry and Materials Science Jinan University Guangzhou China.
Chongyang LiCollege of Chemistry and Materials Science Jinan University Guangzhou China.
Miao MengCollege of Chemistry and Materials Science Jinan University Guangzhou China.
Shijie LiClinical Medical College of Acupuncture Moxibustion and Rehabilitation Guangzhou University of Chinese Medicine Guangzhou China.
Mei TuCollege of Chemistry and Materials Science Jinan University Guangzhou China.
Jacky W Y LamDepartment of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and Technology Kowloon Hong Kong China.
Guangle NiuSchool of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing China.
Ming ChenCollege of Chemistry and Materials Science Jinan University Guangzhou China.ORCID https://orcid.org/0000-0003-4071-6604

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Donor-acceptor (D-A) compounds are particularly important in optoelectronic and biological applications. However, they are normally synthesized in the presence of transition metal catalysts. Herein, we report a metal-free method by a complex-mediated nucleophilic aromatic substitution of aryl nitriles with amines. The method can lead to rich D-A type aggregation-induced emission luminogens (AIEgens) with tunable properties. They emit from deep-blue to yellow-green and possess high photoluminescence quantum yields up to 70.5% in the aggregate state. Interestingly, the suppression of intramolecular flapping is proved to play an indispensable role in the AIE behavior, which is different from the mechanism met in other AIEgens. Moreover, the biocompatible AIEgens possess specific staining of lipid droplets in HeLa cells and the superiority of identifying fatty liver over traditional Oil Red O staining is exhibited.

Indexed as

aggregation‐induced emissionbioimagingdonor‐acceptor structurenucleophilic aromatic substitution

Identifiers

PMID40671928
PMCPMC12262011

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.