ArticleEFSA journal. European Food Safety Authority2025
Safety and efficacy of a feed additive consisting of 4-hydroxy-2,5-dimethylfuran-3(2H)-one for all animal species other than dogs and cats (ADISSEO France SAS, ADM International Sàrl, Laboratoires Phodé S.A.S., LUCTA S.A., Norel, S.A.).
Article in EFSA journal. European Food Safety Authority, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the authorisation of a feed additive consisting of 4-hydroxy-2,5-dimethylfuran-3(2H)-one for all animal species other than dogs and cats. 4-Hydroxy-2,5-dimethylfuran-3(2H)-one is currently authorised for use as a sensory additive (functional group: flavouring compounds) for cats and dogs at a recommended maximum content of 18 and 25 mg/kg complete feed, respectively. The FEEDAP Panel concludes that the use of the additive 4-hydroxy-2,5-dimethylfuran-3(2H)-one at the maximum use level proposed by the applicants (10 mg/kg complete feed) is safe for all animal species other than cats and dogs. 4-Hydroxy-2,5-dimethylfuran-3(2H)-one is safe for consumer and environment, however, it is irritant to skin, eyes and is a dermal and respiratory sensitiser. It should be considered irritant to the respiratory tract. Any exposure is considered a risk. 4-Hydroxy-2,5-dimethylfuran-3(2H)-one is used in food as a flavouring and its function in feed is essentially the same as that in food. Moreover, the Panel notes that the additive is already authorised in feed for cats and dogs. Therefore, no further demonstration of efficacy is necessary.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.