ArticleFrontiers in veterinary science2025
A novel L1C.5 RFLP-1-4-4 recombinant porcine reproductive and respiratory syndrome virus between wild-type virus and a modified-live virus vaccine is highly pathogenic to piglets.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Emergence of a Novel Porcine Reproductive and Respiratory Syndrome Virus 2 Strain Recombined from Two Modified Live Virus-like Strains and Its Pathogenicity for Piglets.Animals : an open access journal from MDPI · 2026Article
- Genetic evolutionary and pathogenicity analyses of a novel porcine reproductive and respiratory syndrome virus 1 strain SC202404 that emerged in Southwestern China.BMC veterinary research · 2026Article
- Development of a novel duplex crystal digital PCR for the detection of PRRSV-1 and PRRSV-2.Frontiers in cellular and infection microbiology · 2026Article
- Genetic and Pathogenic Characteristics of an Emerging Lineage 7 PRRSV-2 (Prime Pac-Like) Strain in China.Transboundary and emerging diseases · 2025Article
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9 authors.
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Abstract
Porcine reproductive and respiratory syndrome (PRRS) is a severe viral disease in pigs caused by porcine reproductive and respiratory syndrome virus (PRRSV). It poses a severe threat to the global swine breeding industry. Recently, the emergence of PRRSV lineage 1C.5 in the United States and China with the RFLP 1-4-4 pattern has raised worldwide attention; however, there are few studies on the genome and pathogenic characteristics of the L1C.5 RFLP 1-4-4 PRRSV in China. In this study, a novel PRRSV-2 variant, designated GX2024, was isolated from a RespPRRS MLV-vaccinated piglet in China using Marc-145 cells and porcine alveolar macrophages (PAMs). The complete viral genome was further determined and analyzed. Phylogenetic analysis of its ORF5 gene showed that GX2024 belonged to PRRSV-2 L1C.5 (RFLP-1-4-4) group, whereas the complete genome sequence clustered into L8E (JXA1-like) group and it contains a discontinuous 131-aa deletion in NSP2 when compared to the NADC30 strain. Notably, recombination analyses indicated that GX2024 is a multiple recombinant virus from two wild-type PRRSVs L1C.5 (NADC30-like) and L8E (JXA1-like), and a RespPRRS MLV vaccine (L5A) strain. To tested the pathogenicity of GX2024, nine four-week-old piglets were divided into two groups (GX2024-challenge group,
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