ArticleResearch square2025
A single residue change only differing by an atomic group can drive imprinting to influenza.
Abstract readPreprint
In one paragraph
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Updated by
Authors and funding
35 authors.
Jiayi SunDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Gyunghee JoDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-7221-2561
Chloe A TroxellDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.ORCID 0009-0003-9647-324X
Yanbin FuDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Robert HoezlDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0009-2536-8219
Huibin LvDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0003-2218-0076
Hassanein H AbozeidInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Qi Wen TeoDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Tossapol PholchareeDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Joshua J C McGrathDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-9267-5501
Siriruk ChangrobDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-1826-4333
Sean A NelsonDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Atsuhiro YasuharaDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Min HuangDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Nai-Ying ZhengDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Jordan C ChervinDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Lei LiDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Monica L Fernández-QuinteroDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Johannes R LoefflerDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Alesandra J RodriguezDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Jiachen HuangDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Olivia M SwansonDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-8162-8358
Angel BalmasedaSustainable Sciences Institute, Managua, Nicaragua.
Guillermina KuanSustainable Sciences Institute, Managua, Nicaragua.
Lora CampredonDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
E Kaitlynn AllenDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-3067-751X
Gabriele NeumannInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Nicholas C WuDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-9078-6697
Yoshihiro KawaokaInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-5061-8296
Florian KrammerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-4121-776X
Paul G ThomasDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-7955-0256
Aubree GordonDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9352-7877
Andrew B WardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-7153-3769
Julianna HanDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0002-3402-2609
Patrick C WilsonDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-3537-1245
Funding
COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4MHousehold Respiratory Virus SARS-CoV-2 Transmission and Immunity Sub-Study (HRTS)U01AI144616 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GORDON, AUBREE L, THOMAS, PAUL G. · 2019 to 2025
$43.7MProject 2U19AI168632 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Octavio Ramilo · 2022 to 2026
$10.2MA deep longitudinal analysis of next generation influenza vaccines in older adultsU01AI165452 · NIAID · JACKSON LABORATORY · PI Adolfo Garcia-Sastre, GEORGE A KUCHEL · 2022 to 2026
$9.0MComputational Models of Adaptive Immunity to InfluenzaU01AI187063 · NIAID · UNIVERSITY OF CHICAGO · PI Sarah Cobey · 2025 to 2026
$2.4MNIAID NIH HHS 75N93019C00051NIAID NIH HHS HHSN272201400005CNIAID NIH HHS U01 AI144616NIAID NIH HHS U01 AI165452NIAID NIH HHS U01 AI187063NIAID NIH HHS U19 AI168632
Abstract
First described as original antigenic sin (OAS), which is deleterious, or now immune imprinting, which also accounts for beneficial effects, it is clear that immune responses to viruses tend to be biased by previous exposure to similar strains
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.