ArticleResearch square2025
Genetic association of preeclampsia to von Willebrand factor and its size-regulator ADAMTS13.
A Inkeri Lokki, Michael Triebwasser, Emma Daly, Mitja I Kurki, Markus Perola, Kirsi Auro, Anuja Java, Jane E Salmon, Seppo Heinonen, Eero Kajantie and 6 more
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
16 authors.
A Inkeri LokkiUniversity of Helsinki.
Michael TriebwasserUniversity of Michigan.
Emma DalyHospital and Harvard Medical School.
Mitja I KurkiUniversity of Helsinki.
Markus PerolaNational Institute for Health and Welfare.
Kirsi AuroNational Institute for Health and Welfare.
Anuja JavaWashington University School of Medicine.
Jane E SalmonWeill Medical College of Cornell University.
Seppo HeinonenUniversity of Helsinki and Helsinki University Hospital.
Eero KajantieNorwegian University of Health and Technology.
Juha KereKarolinska Institutet.
Riitta LassilaUniversity of Helsinki, Helsinki University Hospital.
Mark DalyUniversity of Helsinki.
John P AtkinsonWashington University School of Medicine.
Hannele LaivuoriTampere University.
Seppo MeriUniversity of Helsinki.
Funding
Advancing Child Health Through Cellular and Molecular BiologyK12HD028820 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Donna M. Martin · 2002 to 2026
$9.2MViral Discovery in Rheumatoid ArthritisP30AR048335 · NIAMS · WASHINGTON UNIVERSITY · PI HSIEH, CHYI S · 2001 to 2015
$8.9MTranslational Research Skills Development CoreU54HL112303 · NHLBI · WASHINGTON UNIVERSITY · PI SADLER, J EVAN · 2012 to 2016
$8.8MWashington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Christine T. Pham · 2018 to 2026
$7.6MINTRACELLULAR C3 PROTEINS: SOURCE, COMPOSITION, TRAFFICKING AND FUNCTIONR01GM099111 · NIGMS · WASHINGTON UNIVERSITY · PI ATKINSON, JOHN · 2011 to 2019
$2.7MDefining the Complosome in Human Cells, Tissues and Disease StatesR35GM136352 · NIGMS · WASHINGTON UNIVERSITY · PI ATKINSON, JOHN · 2020 to 2024
$2.0MThe Role of Complement in the Pathogenesis of PreeclampsiaF30HL103072 · NHLBI · WASHINGTON UNIVERSITY · PI TRIEBWASSER, MICHAEL PAUL · 2010 to 2013
$147kNHLBI NIH HHS F30 HL103072NHLBI NIH HHS U54 HL112303NIAMS NIH HHS P30 AR048335NIAMS NIH HHS P30 AR073752NICHD NIH HHS K12 HD028820NIGMS NIH HHS R01 GM099111NIGMS NIH HHS R35 GM136352
6 · The paper itselfAbstract
Preeclampsia is a common pregnancy-specific vascular disorder that develops during the second half of pregnancy. Preeclampsia shares features with thrombotic microangiopathies. Here we analyzed whether sequence variants in the coagulation system genes predispose to preeclampsia. We performed targeted exomic sequencing of 58 genes in a total of 615 preeclamptic women and 2094 controls. A common missense variant rs1800385 (Val1565Leu) in the gene coding for von Willebrand Factor (
Indexed as
ADAMTS13coagulation cascadegenetic associationpreeclampsiapregnancyvon willebrand factor
Identifiers
PMID40671815
PMCPMC12265156
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