ArticleResearch square2025
Socioeconomic Differences in Global Brain Asymmetry: An Integrative Approach Using Image Similarity Measures and Structural Equation Modeling.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The typical human brain exhibits a bilateral asymmetry that can be observed in the distribution of grayscale levels in brain magnetic resonance imaging (MRI). This asymmetry plays a crucial role in the development of higher-level cognition and can be influenced by both socioeconomic and biological factors. In this regard, the objective of this article is to investigate the relationship between brain asymmetry and socioeconomic status (SES) as the primary focus, alongside age and sex. To achieve this, we develop a global index of brain asymmetry using a novel methodology that combines two statistical tools in an innovative manner: the Gradient Magnitude Similarity Deviation image similarity measure, which assesses asymmetries in 2D slices of MRI, and Multiple Indicators Multiple Causes Structural Equation Modeling (MIMIC), which integrates the asymmetry of the 2D slices into a single global index. Our study, conducted on a dataset of 132 healthy individuals, reveals a significant association between SES and brain asymmetry, with individuals of higher SES displaying more pronounced asymmetry compared to those of lower SES. Additionally, asymmetry tends to increase with age, and males exhibit higher asymmetry than females. These findings provide new insights into the association between socioeconomic factors and brain asymmetry, highlighting the relevance of SES in relation to structural brain characteristics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.