Evidence map›Paper›PMID 40671790›Full record

ArticleResearch square2025

Differential susceptibility to colonic ulceration in mice with genetic deletion of

Masako Nakanishi, Michael J Martinez, Patrycja Sztachelski, Marion Leclerc, Daniel W Rosenberg

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Masako NakanishiUniversity of Connecticut Health Center: UConn Health.ORCID 0000-0002-2170-5216
Michael J Martinez
Patrycja Sztachelski
Marion Leclerc
Daniel W Rosenberg

Funding

UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
Cell specific blockade of PGE2 formation in the colonR03CA235225 · NCI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ROSENBERG, DANIEL WILLIAM · 2019 to 2020
$164k
Impact of prostanoid metabolism on colon tumor developmentR03CA235232 · NCI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI NAKANISHI, MASAKO · 2019 to 2020
$164k
NCATS NIH HHS UL1 TR001417NCI NIH HHS R03 CA235225NCI NIH HHS R03 CA235232
6 · The paper itself

Abstract

Background: Prostaglandin E Methods: Mucosal ulcerations were characterized in Results: Progressive colonic ulcerations develop spontaneously in Conclusions: These results suggest that genetic blockage of

Indexed as

colonic ulcerationgut microbiomeinflammatory bowel disease (IBD)mouse modelsmPGES-1non-steroidal anti-inflammatory drugs (NSAIDs)PGE2

Identifiers

PMID40671790
PMCPMC12265163

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.