Evidence map›Paper›PMID 40671784›Full record

ArticleJournal of surgical case reports2025

Use of personalized graft cage and RIA bone graft in a case of acute infection following a grade 2 open tibial shaft fracture: a new option for bone grafting in patients with critical size segmental bone defects.

Christian Thomas Hübner, Anna Veenstra, Felix Karl-Ludwig Klingebiel, Tobias Bayer, Vincent Landre, Sandro-Michael Heining, Christian Hierholzer, Hans-Christoph Pape

Abstract readCase Reports
In one paragraph

Article in Journal of surgical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christian Thomas HübnerDepartment of Trauma, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.ORCID https://orcid.org/0009-0003-9285-8660
Anna VeenstraDepartment of Trauma, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.
Felix Karl-Ludwig KlingebielDepartment of Trauma, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.
Tobias BayerDepartment of Trauma, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.
Vincent LandreDepartment of Trauma, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.
Sandro-Michael HeiningDepartment of Trauma, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.
Christian HierholzerDepartment of Trauma, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.
Hans-Christoph PapeDepartment of Trauma, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Critical size segmental bone defects represent a challenging problem. Recently, personalized, structured three-dimensional graft cages have been developed to improve ingrowth of autologous bone material and reduce resorption. A 44-year-old patient presented with an open tibial shaft fracture after a motorcycle incident with minor bone loss. Following intramedullary nailing, an acute infection developed that required removal of ~4 cm bone in a circular mode. After multiple interventions, a personalized 3D-printed graft cage was implanted and filled with autologous bone material, harvested by intramedullary reaming from the ipsilateral femur. Ten months postoperatively, the patient is completely pain free and shows good clinical and radiological status. In conclusion, use of a 3D-printed graft cage in combination with Reamer Irrigator Aspirator (RIA) might represent a new additional feature for larger bone defects to avoid gravity or perfusion related resorption of large area defects.

Indexed as

bone defectsgraft cageinfectionsintramedullary fracture fixationMasquelet techniquetibial fracturestrauma

Identifiers

PMID40671784
PMCPMC12264204

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.