Evidence map›Paper›PMID 40671779›Full record

ArticleGland surgery2025

Association of thyroglobulin antibody and thyroid peroxidase antibody status with aggressive features in papillary thyroid carcinoma with Hashimoto's thyroiditis.

Qianqian Lu, Yunzhe Dou, Tian Yu, Xing Ren, Yao Li, Xiaoquan Zhu, Yanyang Zhao, Gang Miao

Abstract read
In one paragraph

Article in Gland surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Sphingolipid Metabolism in the Pathogenesis of Hashimoto's Thyroiditis.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qianqian LuDepartment of General Surgery, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Yunzhe DouDepartment of General Surgery, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Tian YuDepartment of Gastrointestinal Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Xing RenDepartment of General Surgery, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Yao LiDepartment of General Surgery, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Xiaoquan ZhuThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, China.
Yanyang ZhaoThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, China.
Gang MiaoDepartment of General Surgery, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0009-0007-2692-0744

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Thyroglobulin antibody (TgAb) and thyroid peroxidase antibody (TPOAb) are thought to be linked to the development and prognosis of papillary thyroid carcinoma (PTC) combined with Hashimoto's thyroiditis (HT). However, the association between TgAb and TPOAb statuses and aggressive features in PTC with HT remains unclear. This study aims to elucidate the invasive or protective effects of different TgAb and TPOAb statuses in PTC patients with HT. Methods: A total of 317 patients who were pathologically diagnosed with PTC and HT were enrolled in this retrospective study. Data on preoperative serum TgAb, TPOAb, and thyroid hormone levels, as well as histopathological and ultrasound characteristics, were collected and analyzed. Based on TgAb and TPOAb status, patients were divided into four groups. The Kruskal-Wallis H test and Pearson chi-squared test were applied to compare aggressive features between the groups. Results: In our study, we enrolled 317 patients, who were divided into four groups based on TgAb and TPOAb status. Significant differences were found between groups in tumor size >4 cm (P=0.004), the number of central lymph node metastases (NCLNM, P=0.01), the central lymph node metastasis ratio (CLNMR, P=0.03), and the lateral lymph node metastasis ratio (LLNMR, P=0.01). Then we conducted pairwise comparisons between groups, which showed that the TgAb and TPOAb double-negative (TAb Conclusions: The TAb

Indexed as

aggressive featuresHashimoto’s thyroiditis (HT)papillary thyroid carcinoma (PTC)Thyroglobulin antibody and thyroid peroxidase antibody status (TgAb and TPOAb status)

Identifiers

PMID40671779
PMCPMC12261382

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.