ArticleGland surgery2025
Ultrasound-guided fine-needle aspiration biopsy of parathyroid adenomas in patients undergoing parathyroidectomy does not lead to clinically significant fibrosis.
Article in Gland surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Fine-needle-based localization techniques in parathyroid adenomas: a retrospective cohort study of histopathological safety and fibrosis patterns.Diagnostic pathology · 2026Article
- Interventional Radiology in the Management of Parathyroid Disorders: Current Diagnostic and Therapeutic Approaches.Journal of clinical medicine · 2026Review
- Molecular Imaging in Parathyroid Carcinoma Management: A Comprehensive Review.Life (Basel, Switzerland) · 2025Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Preoperative localization of parathyroid adenomas (PAs) with ultrasound-guided fine-needle aspiration (USG-FNA) is a controversial subject due to concerns about fibrosis. This paper attempts to evaluate the impact of fine-needle aspiration (FNA) on PA fibrosis in patients with primary hyperparathyroidism (PHPT) undergoing surgical resection. Methods: This retrospective review analyzed 70 patients who underwent parathyroidectomy for PHPT. Forty patients with unequivocal parathyroid lesions underwent USG-FNA using 25- or 27-gauge needles. Postoperatively, an independent pathologist assessed fibrosis in biopsied adenomas in a blinded fashion. Patients undergoing parathyroidectomy without biopsy served as controls. Surgical outcomes and fibrosis scores were compared between the two groups studied. Results: No significant difference in fibrosis scores was observed between biopsied and non-biopsied adenomas by an independent pathologist in cytopathology evaluation (P=0.99). However, ultrasound (US) demonstrated superior localization accuracy (95.8%), in comparison to Single-Photon Emission Computed Tomography-Sestamibi (SPECT-Sestamibi) study (50%). Patients with positive FNA parathyroid hormone (PTH) washout had a higher cure rate (95%) compared to those without biopsy proven localization (67%). Conclusions: Parathyroid FNA biopsy washout with 25- or 27-gauge needles does not cause clinically significant fibrosis. Preoperative localization with positive PTH washout using FNA improves surgical success rates in patients with PHPT.
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