ArticleGland surgery2025
Symphony of rebirth: a retrospective comparative cohort study on heterologous breast reconstruction after radiotherapy.
Article in Gland surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Clinical outcomes of synthetic absorbable mesh use in breast surgery: First case series in reconstruction and aesthetic mastopexy.JPRAS open · 2026Article
- Patterns and costs of breast reconstruction in Chinese plastic surgery department: a study from national quality control databases (2022-2023).Gland surgery · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: While radiotherapy is a fundamental component of breast-conserving therapy for early breast cancer, it can complicate subsequent reconstructive procedures due to its impact on tissue quality. Despite the growing use of implant-based reconstruction, limited data are available on its safety and aesthetic outcomes in patients previously treated with radiotherapy. This study aims to evaluate the effectiveness and safety of heterologous breast reconstruction using tissue expanders and implants in irradiated patients compared to non-irradiated controls. Methods: This retrospective comparative cohort study included patients who underwent mastectomy with heterologous reconstruction between January 2020 and December 2023. Patients were divided into two groups: those with prior radiotherapy following breast-conserving surgery for local recurrence (PRS group) and those without prior radiotherapy (NPRS group). All irradiated patients received a standardized regimen of 50 Gy in 25 fractions. Reconstructions were performed using either prepectoral or subpectoral techniques, with Ti-Loop Results: A total of 175 patients were included: 15 in the PRS group and 160 in the NPRS group. No statistically significant differences were found in postoperative complication rates, including hematoma (13% PRS Conclusions: Implant-based breast reconstruction appears to be a viable option for patients with prior radiotherapy when performed with careful planning and standardized protocols. However, due to the small sample size of the irradiated group and limited follow-up duration, larger and longer-term studies are needed to validate these findings and assess long-term complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.