ArticleInfection and drug resistance2025
Trends in Drug Resistance and Epidemiological Patterns of Tuberculosis in Elderly Patients in Wenzhou, China (2014-2023).
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Clinical and Microbiological Characteristics Associated with Treatment Outcomes Among Rifampicin-Resistant Tuberculosis Patients in Limpopo Province.Infection and drug resistance · 2026Article
- Drug Resistance Patterns, Temporal Trends, and Risk Factors Among Elderly Tuberculosis Patients in Anhui, China: A Retrospective Study (2020-2024).Infection and drug resistance · 2026Article
- Urban Chinese Community-Dwelling Older Adults' Expectations Regarding the Delivery of Integrated Care Through Case Managers: Protocol for a Mixed Methods Study.JMIR research protocols · 2025Article
- Prevalence and epidemiological pattern of drug-resistant tuberculosis among migrant populations in Wenzhou City, China, 2014-2023: implications for public health strategies.Frontiers in public health · 2025Article
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Abstract
Purpose: This study aimed to elucidate the epidemiological features, drug resistance patterns, and temporal trends among elderly tuberculosis (TB) patients in Wenzhou, China, from 2014 to 2023, providing insights for targeted TB control strategies. Patients and Methods: Data were extracted from 10,993 TB patients registered in the Laboratory Information System of Wenzhou Central Hospital and the Tuberculosis Information Management System of the Chinese Center for Disease Control and Prevention. Patients were divided into elderly (≥60 years, n=2,727) and non-elderly (<60 years, n=8,266) groups. Sociodemographic, clinical, and phenotypic drug susceptibility testing data were analyzed using chi-square tests. Temporal trends in drug resistance were assessed via Joinpoint regression to estimate annual percentage changes (APC). Results: The elderly group had higher proportions of males (79.65% vs 69.66%), Han ethnicity (99.63% vs 96.35%), and lesions involving ≥3 lung fields (42.35% vs 32.62%), but lower proportions of migrants (20.32% vs 51.20%), urban residents (41.03% vs 53.41%), employed individuals (8.98% vs 32.91%), and pulmonary cavitation (46.75% vs 53.54%). The overall drug-resistant tuberculosis (DR-TB) rate was similar between the elderly and non-elderly groups (20.76% vs 20.30%). However, the elderly group had lower rates of streptomycin (SM) resistance (11.07% vs 12.62%), rifampicin (RFP) resistance (6.20% vs 8.06%), and multidrug-resistant tuberculosis (MDR-TB) (5.39% vs 7.10%). From 2014 to 2023, the overall DR-TB rate among elderly patients decreased from 31.58% to 20.64% (-34.63%), with a significant decline in MDR-TB (APC of -9.9%). Resistance to isoniazid (INH) decreased from 2016 to 2023 (APC -4.0%), and RFP resistance decreased from 2014 to 2021 (APC -10.7%). Significant decreases were also observed among migrant populations (APC -10.1%, 2014-2020), urban residents (APC -8.7%, 2014-2021), and unemployed individuals (APC -4.3%, 2014-2023). Conclusion: Our study revealed that drug resistance among elderly TB patients in Wenzhou has decreased over the past decade, particularly for MDR-TB and key first-line drugs. However, the elderly group still exhibited distinct epidemiological and drug resistance profiles compared to younger patients. These findings offer clear suggestions for public health policy-making and clinical practice, which can help further reduce the burden of tuberculosis and drug resistance in the elderly population.
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