Evidence map›Paper›PMID 40671751›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2025

Real-time dosimetry using scintillator technology in external beam radiation therapy (EBRT).

Baozhu Lu, Yifeng Zhu, Brook Byrd, Daniel Alexander, John P Plastaras, Taoran Li, Lisha Chen, Brian W Pogue, Timothy C Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Baozhu LuDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Yifeng ZhuDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Brook ByrdDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Daniel AlexanderDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
John P PlastarasDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Taoran LiDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Lisha ChenDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Brian W PogueDepartment of Medical Physics, University of Wisconsin-Madison, Hanover, NH, USA.
Timothy C ZhuDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.

Funding

Cherenkov imaging incorporating 3D surface imaging for TSETR01CA274411 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ZHU, TIMOTHY C. · 2022 to 2025
$2.1M
Cherenkov imaging of Total Skin Electron Therapy (TSET)R21CA239127 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ZHU, TIMOTHY C. · 2020 to 2021
$386k
NCI NIH HHS R01 CA274411NCI NIH HHS R21 CA239127
6 · The paper itself

Abstract

Total Skin Electron Therapy (TSET) is a specialized radiotherapy technique used for the treatment of cutaneous T-cell lymphoma and other diffuse skin malignancies. Accurate real-time dosimetry is essential for ensuring precise dose delivery while minimizing toxicity to healthy tissues. This study presents the development and implementation of an advanced scintillator-based real-time dosimetry system designed to enhance dosimetry precision in TSET, utilizing a source-to-surface distance (SSD) of 5 meters with an intervening spoiler to optimize dose distribution. In a phantom study, nine scintillators were vertically positioned 20 cm apart on a white PVC board, alongside diodes that served as absolute dose references. Scintillator signals were captured using Cherenkov imaging cameras and fitting with correction factors were applied to ensure consistency between scintillator and diode-based dose measurements. Additionally, in vivo patient data were analyzed, revealing variations in scintillator response depending on positioning and camera selection. The results indicate that scintillators provide a feasible solution for real-time dosimetry in TSET, contingent upon strict regulation of scintillator placement and patient posture. Further optimization and standardization of scintillator positioning are necessary to enhance clinical implementation and dosimetry accuracy, ensuring reliable and precise dose monitoring in TSET applications.

Indexed as

Cherenkov imagingDose monitoring and optimizationReal-time dosimetryScintillator-based detectionTotal Skin Electron Therapy (TSET)

Identifiers

PMID40671751
PMCPMC12266726

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.