Evidence map›Paper›PMID 40671732›Full record

ArticleJournal of diabetes and metabolic disorders2025

Effects of pomegranate peel powder-fortified bread consumption in patients with type 2 diabetes mellitus: randomized controlled trial.

Maryam Zare, Atefe Rezaei, Mozhgan Karimifar, Mohammad Javad Tarrahi, Sahar Saraf-Bank, Sayed Amir Hossein Goli, Reza Amani

Abstract read
In one paragraph

Article in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maryam ZareDepartment of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID 0000-0003-1251-5100
Atefe RezaeiDepartment of Food Science and Technology, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; School of Life Sciences, Plant Proteins and Nutrition, Technical University of Munich, 85354 Munich, Freising Germany.ORCID 0000-0003-1275-4603
Mozhgan KarimifarIsfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID 0000-0002-1175-1729
Mohammad Javad TarrahiEpidemiology and Biostatistics Department, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID 0000-0001-7875-4572
Sahar Saraf-BankNutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID 0000-0003-3443-9559
Sayed Amir Hossein GoliDepartment of Food Science and Technology, College of Agriculture, Isfahan University of Technology, Isfahan, Iran.ORCID 0000-0001-9910-8019
Reza AmaniDepartment of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID 0000-0002-0074-4080

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Type 2 diabetes mellitus (T2DM) poses a huge global disease burden due to high morbidity and mortality rates. Dietary modifications can significantly regulate T2DM risk factors. This study primarily aimed to investigate the effects of bread fortified with pomegranate peel powder (PPP) on glycemic control, lipid profile, and anthropometric measures in patients with T2DM. Methods: PPP was added to bread by adding 0, 1.5, 2.5, 3.5, and 5% PPP. We measured the phenol content by Folin-Ciocalteu and the antioxidant activity via DPPH (2,2-diphenyl-1-picrylhydrazyl). Ninety participants were then allocated to a randomized parallel controlled intervention study, and the effects of consuming 100 g/day of bread with PPP (3.5%) on glycemic markers, lipid profiles, and anthropometrics were assessed. The bread administered to the control group was the same as that used for the intervention group except for the absence of PPP. Results: The PPP-fortified bread contained greater polyphenol levels and antioxidant activity than the bread without PPP. Compared to the control bread, fortified bread with PPP showed no significant effects on anthropometric measures, blood pressure, glycemic levels, and lipid markers after adjusting for age, sex, and caloric intake. Conclusions: In comparison with control bread, PPP bread does not show much effect on glycemic parameters, lipid profile, and anthropometric measurements. Extended duration, different doses, and larger sample sizes are advisable for further studies. Trial registration: IRCT20191209045672N1 is the trial ID in the Iranian Registry of Clinical Trials. Date of registration 21/09/2020. https//en.irct.ir/trial/48,132. Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-025-01672-y.

Indexed as

Diabetes mellitusGlycemicLipid profilePomegranate

Identifiers

PMID40671732
PMCPMC12259516

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.