Evidence map›Paper›PMID 40671716›Full record

ArticleNature reviews bioengineering2025

The emerging era of structural nanomedicine.

Chad A Mirkin, Milan Mrksich, Natalie Artzi

Abstract read
In one paragraph

Article in Nature reviews bioengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Metal-Phenolic Coatings Enable Universal Design of Spherical Nucleic Acids.Angewandte Chemie (International ed. in English) · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. E7Science advances · 2026
    Article
  11. Article
  12. Antibody-Empowered Nanomedicine for Precise Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Gold Nanoparticles Guided by Self-Assembling Peptides: From Sequence to Superstructure.Chembiochem : a European journal of chemical biology · 2025
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chad A MirkinDepartment of Chemistry, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0002-6634-7627
Milan MrksichDepartment of Chemistry, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0002-4964-796X
Natalie ArtziBrigham and Women's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard, Medical School, Boston, Massachusetts 02215, USA.ORCID 0000-0002-2211-6069

Funding

Resource Development CoreU54DK137516 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Eun Ji Paige Chung, Pinelopi P. Kapitsinou · 2023 to 2026
$4.8M
Innovative Research for Cancer Nanotechnology (IRCN) for Enhancing Melanoma-specific Immune Responses by the Rational Design of Spherical Nucleic AcidsR01CA257926 · NCI · NORTHWESTERN UNIVERSITY · PI CHAD A. MIRKIN, Bin Zhang · 2022 to 2026
$2.5M
Spherical Nucleic Acid nano-architectures as first-in-class cGAS agonists for the immunotherapeutic treatment of Glioblastoma.R01CA275430 · NCI · WASHINGTON UNIVERSITY · PI MIRKIN, CHAD A., STEGH, ALEXANDER H. · 2022 to 2025
$2.3M
NCI NIH HHS R01 CA257926NCI NIH HHS R01 CA275430NIDDK NIH HHS U54 DK137516
6 · The paper itself

Abstract

The lack of structural definition in nanomedicines limits therapeutic efficacy and complicates regulatory approval. Here, we emphasize that defining, designing and optimizing the structures of nanomedicine are critical to developing effective therapies because their architectures - not just the identity of their components - determines potency.

Identifiers

PMID40671716
PMCPMC12263095

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.