Evidence map›Paper›PMID 40671675›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2025

Neo-antigen tumor vaccination depends on CD4-licensing conveyed by adeno-associated virus like particles.

Lasse Neukirch, Silke Uhrig-Schmidt, Katharina von Werthern, Alexandra Tuch, Joscha A Kraske, Yanhong Lyu, Benedicte Lenoir, Stefan B Eichmüller, Marten Meyer, Inka Zörnig and 2 more

Abstract read
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lasse NeukirchClinical Cooperation Unit "Applied Tumor Immunity", German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, Heidelberg, Germany.
Silke Uhrig-SchmidtClinical Cooperation Unit "Applied Tumor Immunity", German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, Heidelberg, Germany.
Katharina von WerthernClinical Cooperation Unit "Applied Tumor Immunity", German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, Heidelberg, Germany.
Alexandra TuchClinical Cooperation Unit "Applied Tumor Immunity", German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, Heidelberg, Germany.
Joscha A KraskeDepartment of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Im Neuenheimer Feld 460, Heidelberg, Germany.
Yanhong LyuClinical Cooperation Unit "Applied Tumor Immunity", German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, Heidelberg, Germany.
Benedicte LenoirClinical Cooperation Unit "Applied Tumor Immunity", German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, Heidelberg, Germany.
Stefan B EichmüllerGMP and T Cell Therapy Group, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany.
Marten MeyerClinical Cooperation Unit "Applied Tumor Immunity", German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, Heidelberg, Germany.
Inka ZörnigDepartment of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Im Neuenheimer Feld 460, Heidelberg, Germany.
Dirk JägerClinical Cooperation Unit "Applied Tumor Immunity", German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, Heidelberg, Germany; Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Im Neuenheimer Feld 460, Heidelberg, Germany.
Patrick SchmidtDepartment of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Im Neuenheimer Feld 460, Heidelberg, Germany; GMP and T Cell Therapy Group, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany. Electronic address: patrick.schmidt@nct-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Personalized treatment has become a realistic option for tumor patients, accelerated by significantly reduced sequencing costs of tumor genomes and advances in vaccine formulations. The druggability of cancer neo-antigens caused by individual mutations is centered in this effort. We here use an adeno-associated virus (AAV)-based virus-like particle (VLP) platform to compose a neo-antigen-specific protein vaccine that is effective in a murine prevention and treatment setting. Furthermore, we show that CD4

Indexed as

Antigens, NeoplasmCancer VaccinesCD4-Positive T-LymphocytesDependovirusVaccines, Virus-Like ParticleAnimalsCD8-Positive T-LymphocytesCell Line, TumorFemaleGenetic VectorsHistocompatibility Antigens Class IIHumansMiceVaccinationAntigens, NeoplasmCancer VaccinesHistocompatibility Antigens Class IIVaccines, Virus-Like ParticleAAVLPCD4 licensingimmunotherapyneo-antigenvaccine

Identifiers

PMID40671675
PMCPMC12848249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.