Evidence map›Paper›PMID 40671632›Full record

ArticleACS infectious diseases2025

Discovery of a Widespread Polyamine-Low-Molecular-Weight Thiol Hybrid Pathway in

Rachelle L Hunt, Joonseok Oh, Abhishek Jain, Ting-Hao Kuo, Domenica Berardi, Wenya Jian, Deguang Song, Qihao Wu, Andrew L Goodman, Noah W Palm and 3 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rachelle L HuntDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Joonseok OhDepartment of Chemistry, Yale University, New Haven, Connecticut 06511, United States.
Abhishek JainDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06510, United States.ORCID 0000-0002-9702-023X
Ting-Hao KuoEuropean Molecular Biology Laboratory (EMBL), Molecular Systems Biology Unit, Heidelberg 69117, Germany.
Domenica BerardiDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06510, United States.
Wenya JianDepartment of Chemistry, Yale University, New Haven, Connecticut 06511, United States.
Deguang SongDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Qihao WuDepartment of Chemistry, Yale University, New Haven, Connecticut 06511, United States.ORCID 0000-0002-9677-9017
Andrew L GoodmanDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Noah W PalmDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Michael ZimmermannEuropean Molecular Biology Laboratory (EMBL), Molecular Systems Biology Unit, Heidelberg 69117, Germany.
Caroline H JohnsonDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06510, United States.
Jason M CrawfordDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut 06510, United States.ORCID 0000-0002-7583-1242

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Microbial Chemical Sensing and Host ResponsesRM1GM141649 · NIGMS · YALE UNIVERSITY · PI Jason Michael Crawford, Caroline Helen Johnson · 2021 to 2026
$9.0M
Causes and consequences of interpersonal microbial variationR35GM118159 · NIGMS · YALE UNIVERSITY · PI Andrew L Goodman · 2016 to 2026
$5.6M
Predoctoral Training at the Interface Chemistry and BiologyT32GM149444 · NIGMS · YALE UNIVERSITY · PI Jason Michael Crawford · 2023 to 2026
$2.2M
NCATS NIH HHS UL1 TR001863NIGMS NIH HHS R35 GM118159NIGMS NIH HHS RM1 GM141649NIGMS NIH HHS T32 GM149444
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biogenic PolyaminesClostridioides difficileSulfhydryl CompoundsAnimalsBiosynthetic PathwaysClostridium InfectionsColorectal NeoplasmsHumansMiceMicrobiotaBiogenic PolyaminesSulfhydryl Compoundsbacterial natural productsClostridioides difficilegut microbiome metabolismisotopic labelinglow-molecular-weight thiolspolyamines

Identifiers

PMID40671632
PMCPMC12403189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.