Evidence map›Paper›PMID 40671613›Full record

ArticleEmerging microbes & infections2025

Clinical features of a fatal case of acute encephalitis associated with a novel influenza H3N2 recombinant virus possessing human-origin H7N9 internal genes: a descriptive study.

Wenlei Wang, Xuhua Mao, Ming Li, Kaituo Liu, Bo Peng, Qin Su, Zehua Wang, Zhihui Zheng, Zihan Chen, Weiqing Shi and 7 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Wenlei WangThe Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Xuhua MaoThe Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Ming LiThe Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Kaituo LiuJoint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, People's Republic of China.
Bo PengMicrobiology Laboratory, Shenzhen Center for Disease Control and Prevention, Shenzhen, People's Republic of China.
Qin SuThe Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Zehua WangThe Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Zhihui ZhengThe Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Zihan ChenThe Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Weiqing ShiJiangsu Provincial Center for Disease Control and Prevention, Nanjing, People's Republic of China.
Muhammad AliThe Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Yin WangYangzhou Center for Disease Control and Prevention & the Affiliated CDC of Yangzhou University, Yangzhou, People's Republic of China.
Min GuCollege of Veterinary Medicine & Jiangsu Key Laboratory of Human Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, People's Republic of China.
Junjie LuThe Affiliated Yixing Clinical School of Medical School of Yangzhou University, Yangzhou University, Yixing, People's Republic of China.
Xiaoquan WangCollege of Veterinary Medicine & Jiangsu Key Laboratory of Human Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, People's Republic of China.
Xiufan LiuCollege of Veterinary Medicine & Jiangsu Key Laboratory of Human Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, People's Republic of China.
Pinghu ZhangThe Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Newly emerging or "re-emerging" influenza viruses have been regarded as a huge global threat to human public health. However, there are few reports of human deaths caused by newly emerging influenza viruses derived from pigs and poultry. Here, we described the clinical and virological features of a fatal encephalitis caused by a novel H3N2 reassortant virus generated from swine H3N2 and human H7N9 viruses. A 7-year-old boy was diagnosed with acute encephalitis in Yixing, China, in August 2022. Chest computed tomography (CT) showed mild pneumonia. Brain CT indicated acute encephalitis companied brain parenchyma swelling. Haematological examinations revealed a markedly elevation of lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, creatine kinase and cytokines. Pathogenic analysis confirmed that a novel H3N2 virus (A/Yixing/805/2022, YX805) was responsible for this case. Phylogenetic analysis showed that the surface protein-coding genes were originated from swine-origin H3N2 viruses, whereas the internal protein-coding genes were derived from human-origin H7N9 viruses. This virus triggers stronger cytokines storm than these genetically related H7N9 viruses and has a natural resistance to neuraminidase inhibitors. The YX805 virus is highly pathogenic to mice. Our study highlights the urgent need to enhance epidemiological surveys for reassortment events between swine and avian influenza virus by full genome sequencing.

Indexed as

Encephalitis, ViralInfluenza A Virus, H3N2 SubtypeInfluenza A Virus, H7N9 SubtypeInfluenza, HumanOrthomyxoviridae InfectionsReassortant VirusesAnimalsChildChinaFatal OutcomeHumansMalePhylogenySwineH3N2H7N9Influenza-associated encephalitisInfluenza A virusReassortment

Identifiers

PMID40671613
PMCPMC12272670

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.