ArticleThe Journal of clinical endocrinology and metabolism2026
A PTH Value at 6 Hours Postsurgery Predicts the Diagnosis of Transient and Permanent Hypoparathyroidism.
Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
contextPTH+ levels after thyroid surgery are generally used to detect patients at risk of developing postoperative hypoparathyroidism. However, there is still a lack of consensus about the threshold value regarding its evaluation, the definition of gland function recovery, and the classification of hypoparathyroidism as permanent.
objectivePTH levels (determined 6 hours after total thyroidectomy) could be effective for early prediction of the risk of postsurgical hypocalcemia and IV calcium requirements during hospitalization, comparing it with the predictive capacity of serum calcium levels at 24 and 48 hours after surgery. We also aim to study the efficacy of the measurement of PTH levels for the predictive diagnosis of permanent hypoparthyroidism.
designProspective cohort study between September 2021 and November 2023.
settingA public tertiary care hospital (Jaén, Spain). PATIENTS: We collected data on 105 patients undergoing total thyroidectomy.
main outcome measuresPTH levels were measured 6 hours postoperatively. Additionally, corrected calcium levels, adjusted for total protein, were measured at 24 hours and 48 hours postsurgery.
resultsIn our study, a PTH value at 6 hours postsurgery <10.10 pg/mL suggests, with high sensitivity and specificity, to be a very effective measure for identifying patients who would develop either transient [area under the curve (AUC) = 0.991, 95% confidence interval (CI) 0.978-1] and permanent hypoparathyroidism (AUC = 0.961, 95% CI 0.952-0.997).
conclusionMeasuring PTH levels at 6 hours postthyroidectomy is an accurate method for predicting which patients are at risk of developing transient and/or permanent hypoparathyroidism.
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