Evidence map›Paper›PMID 40671564›Full record

Observational studyScience progress

Increased platelet-neutrophil aggregate ratio after severe acute respiratory syndrome coronavirus 2 vaccination and severe infection.

Barbara Réger, Margit Solymár, Sándor Pál, Viktória Temesfői, Attila Miseta, Zsuzsanna Faust

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Barbara RégerDepartment of Laboratory Medicine, University of Pécs, Medical School, Pécs, Hungary.
Margit SolymárDepartment of Laboratory Medicine, Department of Transfusion Medicine, University of Pécs, Medical School, Pécs, Hungary.ORCID 0000-0001-6667-6263
Sándor PálDepartment of Laboratory Medicine, Department of Transfusion Medicine, University of Pécs, Medical School, Pécs, Hungary.ORCID 0000-0002-3993-7947
Viktória TemesfőiJános Szentágothai Research Centre, University of Pécs, Pécs, Hungary.ORCID 0000-0002-2990-6258
Attila MisetaDepartment of Laboratory Medicine, University of Pécs, Medical School, Pécs, Hungary.
Zsuzsanna FaustDepartment of Laboratory Medicine, Department of Transfusion Medicine, University of Pécs, Medical School, Pécs, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectivesPlatelet-neutrophil aggregates (PNA) bridge inflammatory processes with the hemostatic system. The goal of this study was the comparative evaluation of PNAs in healthy individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), septic patients, coronavirus disease 2019 (COVID-19) patients, and a pre-pandemic control group from 2019.MethodsThis observational study involved prospective blood sample collection from vaccinated individuals at separate times after immunization with Pfizer-BioNTech mRNA vaccine, together with the retrospective analysis of laboratory data from COVID-19, sepsis, and control subjects. PNA ratios and anti-S-protein antibody levels were also measured.ResultsFollowing primary SARS-CoV-2 vaccination, PNA levels increased significantly, showing a gradual decline over six months while remaining elevated. Booster vaccinations did not elevate PNA levels. In COVID-19 patients PNA ratios were the highest, while in the patients with sepsis remained comparable to those of the control group. A moderate correlation was found between PNA and anti-S-protein levels after primary immunization (rho = 0.31,

Indexed as

Blood PlateletsCOVID-19COVID-19 VaccinesNeutrophilsSARS-CoV-2SepsisAdultAgedAntibodies, ViralBNT162 VaccineFemaleHumansMaleMiddle AgedProspective StudiesRetrospective StudiesAntibodies, ViralBNT162 VaccineCOVID-19 Vaccinesanti-severe acute respiratory syndrome coronavirus 2 antibodyanti-severe acute respiratory syndrome coronavirus 2 immunizationcoronavirus disease 2019neutrophilsPfizer-BioNTech mRNA vaccinePlatelet–neutrophil aggregatesplatelets

Identifiers

PMID40671564
PMCPMC12276486

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.