Evidence map›Paper›PMID 40671512›Full record

ArticleAddiction biology2025

Amygdala-Ventral Striatum Functional Connectivity Underlies Craving in Gambling Disorder: A Mediating Role of Depressive Symptoms.

Yuzuki Ishikawa, Kentaro Katsuragi, Takahiko Inagaki, Kota Ebina, Yoshiteru Mutsuda, Morio Aki, Mami Shibata, Ayaka Hamamoto, Tsuyoshi Ando, Akihisa Iriki and 10 more

Abstract read
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In one paragraph

Article in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yuzuki IshikawaDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kentaro KatsuragiDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takahiko InagakiDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kota EbinaDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yoshiteru MutsudaDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Morio AkiDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Mami ShibataDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ayaka HamamotoDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tsuyoshi AndoAndo Clinic, Kyoto, Japan.
Akihisa IrikiOsaka Psychiatric Medical Center, Osaka, Japan.
Takashi MiyagiDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hiroto MizutaDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ariyoshi TakemuraDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takuro MuraoDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hideaki TakeuchiDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ryosaku KawadaDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Naoya OishiHuman Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hidehiko TakahashiDepartment of Psychiatry and Behavioral Sciences, Institute of Science Tokyo, Tokyo, Japan.
Toshiya MuraiDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kosuke TsurumiDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0001-5051-6978

Funding

Japan Society for the Promotion of Science 22K15749Japan Society for the Promotion of Science 23H04979Japan Society for the Promotion of Science JP21H05173National Center for Neurology and PsychiatryNational Center of Neurology and Psychiatry 4-1Smoking Research Foundation
6 · The paper itself

Abstract

Craving is an intense, strong urge to engage in addictive behaviours. Craving is supposed to be modulated by the connectivity between the amygdala and the ventral striatum (VS), a pivotal pathway for reward-seeking behaviours. However, whether and how this connectivity underlies craving for gambling remains unclear, limiting our understanding of the pathophysiology of gambling disorder (GD). To address this issue, we analysed resting-state functional connectivity (rs-FC) between the amygdala and VS in 51 GD patients and 45 healthy participants. Craving for gambling was assessed using the Gambling Craving Scale (GACS). Among three GACS subscales, Desire exhibited a significant correlation with rs-FC in the right amygdala-VS, while Anticipation and Relief showed no significant associations. Causal mediation analysis revealed that depressive symptoms significantly mediated the relationship between rs-FC in the right amygdala-VS and Desire. These findings suggest that the amygdala-VS connectivity elicits the intense desire for gambling through negative emotions.

Indexed as

AmygdalaCravingDepressionGamblingVentral StriatumAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysRewardamygdalacraving for gamblingdepressive symptomsgambling disorderventral striatum

Identifiers

PMID40671512
PMCPMC12268111

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.