Observational studyMuscle & nerve2025
Quantitative Muscle Ultrasound: A Non-Invasive Biomarker for Monitoring Duchenne Muscular Dystrophy.
Observational study in Muscle & nerve, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05249361 (Correlation Between Functional Capacity and Functional Capability in Patients With Duchenne Muscular Dystrophy-A Longitudinal Study), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Correlation Between Functional Capacity and Functional Capability in Patients With Duchenne Muscular Dystrophy-A Longitudinal Study
Who cites it
2 citing papers in PubMed.
- Real-time shear wave elastography and high-frequency ultrasound in the assessment of treatment outcomes for triceps surae muscle injury.BMC musculoskeletal disorders · 2026Article
- Quantitative Muscle Ultrasound: A Non-Invasive Biomarker for Monitoring Duchenne Muscular Dystrophy.Muscle & nerve · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
INTRODUCTION/
aimsQuantitative muscle ultrasound (QMUS) shows promise as a non-invasive biomarker for monitoring functional status in Duchenne muscular dystrophy (DMD). We evaluated the correlation between QMUS in various muscles and functional capacity assessments. Additionally, we compared the utility of composite QMUS scores as a comprehensive measure of disease progression to that of single-muscle analyses.
methodsWe analyzed baseline data from an ongoing prospective study involving 23 patients with DMD (aged 5-18 years; mean 10.7; SD 4.2). High-resolution ultrasound scans of muscle groups across the upper and lower limbs, head and neck, and diaphragm were assessed for muscle echogenicity using mean grayscale values (MGV). Functional capacity assessments included the 6-min walk test (6MWT), North Star Ambulatory Assessment (NSAA), Performance of Upper Limb (PUL) module, timed function tests, quantitative muscle strength tests, and respiratory muscle strength tests.
resultsThe composite MGV for upper and lower limbs demonstrated moderate to strong negative correlations with the 6MWT and NSAA scores (correlation coefficient [CC]: -0.44 to -0.74; p < 0.01) and strong to very strong positive correlations with rise-from-floor, 4-stair climb, and 10-m walk/run times (CC: 0.65 to 0.87; p < 0.01). For upper limb function, the MGV of the flexor carpi radialis muscle was negatively correlated with PUL scores (CC = -0.35, p = 0.02). However, no significant correlations were observed between QMUS parameters and muscle strength test (p > 0.05). DISCUSSION: QMUS offers a non-invasive method for assessing muscle changes and tracking disease progression in DMD.
trial registrationClinicalTrials.gov identifier: NCT05249361.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.