Evidence map›Paper›PMID 40671372›Full record

ArticleTherapeutic delivery2025

Controlled transdermal delivery of oxycodone by pulsed iontophoresis: In vitro and in vivo evaluations.

Mahdie Kamalabadi, Arash Ghoorchian, Katayoun Derakhshandeh, Rasool Haddadi

Abstract read
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Article in Therapeutic delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mahdie KamalabadiDepartment of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Arash GhoorchianDepartment of Chemistry, Research Center for Development of Advanced Technologies, Tehran, Iran.
Katayoun DerakhshandehDepartment of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Rasool HaddadiDepartment of Pharmacology Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe imperative challenges in transdermal iontophoresis (IP) are irritation, skin polarization, and patient discomfort. In this paper, we studied the IP delivery of oxycodone (OXC) using continuous direct current (CDC) and pulse depolarization current (PDC) current protocols.

methodsThe different current protocols (CDC, PDC1, PDC2, and PDC3) have been employed to investigate the in vitro transdermal IP of OXC through the rat skin. Moreover, other effective factors including the formulation pH, the magnitude of applied current density, and the NaCl concentration were optimized to obtain the best performance of IP.

resultsThe in vitro permeation experiments demonstrated that the cumulative amount of permeated OXC after 24 h (Q

conclusionThe study can pave the way for developing IP delivery systems using PDC.

Indexed as

Analgesics, OpioidIontophoresisOxycodoneSkinAdministration, CutaneousAnimalsDrug Delivery SystemsHydrogen-Ion ConcentrationMalePermeabilityRatsSkin AbsorptionAnalgesics, OpioidOxycodonecontinuous direct currentIn Vitro and In Vivo studyoxycodonepulse depolarization currentTransdermal iontophoresis

Identifiers

PMID40671372
PMCPMC12502812

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.