Evidence map›Paper›PMID 40671265›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Biomolecular Interaction Prediction: The Era of AI.

Haoping Wang, Xiangjie Meng, Yang Zhang

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Frontiers in pharmacology · 2026
    Review
  7. Review
  8. Special Issue "Biomolecular Structure, Function and Interactions".International journal of molecular sciences · 2025
    Article
  9. Review
  10. Biomolecular Interaction Prediction: The Era of AI.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Haoping WangSchool of Biomedical Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong, 518055, China.
Xiangjie MengSchool of Biomedical Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong, 518055, China.
Yang ZhangSchool of Biomedical Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong, 518055, China.ORCID https://orcid.org/0000-0002-3503-5161

Funding

National Natural Science Foundation of China 82273890Shenzhen Science and Technology Program JCYJ20240813104817024Shenzhen Stable Support Grant GXWD 20231130103401001
6 · The paper itself

Abstract

Predicting biomolecular interactions is a crucial task in drug discovery and molecular biology. Deep learning, with its ability to learn complex patterns from large datasets, has shown promising results in predicting biomolecular interactions. In this review, a comprehensive and accessible overview of deep learning algorithms is aimed to provide that can enhance the prediction of biomolecular interactions using various features, including sequence data, structural information, and functional annotations. The datasets and models for predicting biomolecular interactions using deep learning are summarized. These deep learning models are developed for a wide range of target molecules, including proteins, nucleic acids, and small molecules, thus reducing the time and cost of screening compounds with high binding affinity to a given target. Furthermore, deep learning can also aid in understanding the mechanisms of biomolecular interactions by identifying key residues involved in the interaction, and help in predicting the side effects of drugs by identifying potential off-target interactions. In conclusion, deep learning has the potential to revolutionize drug discovery and improve understanding of molecular biology by providing accurate and efficient prediction in biomolecular interactions.

Indexed as

Deep LearningDrug DiscoveryAlgorithmsHumansProteinsProteinsbiomolecular interactiondeep learningnucleic acidproteinsmall molecule

Identifiers

PMID40671265
PMCPMC12520538

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.