Evidence map›Paper›PMID 40671180›Full record

SynthesisThe journal of trauma and acute care surgery2025

Surgical management of incarcerated and strangulated inguinal hernias requiring urgent surgical intervention: A systematic review, meta-analysis, and practice management guideline from the Eastern Association for the Surgery of Trauma.

Michael S Farrell, Zugui Zhang, Jordan Kirsch, Katie Bower, Curtis Bower, Rondi Gelbard, Alistair J Kent, Konstantin Khariton, Arielle Perez, Emanuele Lo Menzo and 2 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in The journal of trauma and acute care surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michael S FarrellFrom the Department of Surgery (M.S.F.), Lehigh Valley Health Network, Allentown, Pennsylvania; The Institute for Research on Equity and Community Health (Z.Z.), Christiana Care Health System, Newark, Delaware; Department of Surgery (J.K.), Westchester Medical Center, Valhalla, New York; Department of Surgery (K.B., C.B.), Virginia Tech Carilion Clinic, Roanoke, Virginia; Department of Surgery (R.G.), University of Alabama at Birmingham, Birmingham, Alabama; Department of Surgery (A.J.K.), Johns Hopkins Hospital, Baltimore, Maryland; Department of Surgery (K.K.), New York Presbyterian Queens, Queens, New York; Department of Surgery (A.P.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Cleveland Clinic Weston Hospital (E.L.M.), Weston, Florida; Hirsch Health Sciences Library (J.B.R.), Tufts University, Boston, Massachusetts; and Department of Surgery (A.R.), Christiana Care Health System, Newark, Delaware.ORCID 0000-0001-7665-2775
Zugui Zhang
Jordan Kirsch
Katie Bower
Curtis Bower
Rondi Gelbard
Alistair J Kent
Konstantin Khariton
Arielle Perez
Emanuele Lo Menzo
Judy B Rabinowitz
Asanthi Ratnasekera

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Megan M Wenner · 2013 to 2026
$60.5M
NIGMS NIH HHS U54 GM104941
6 · The paper itself

Abstract

backgroundPatients with acutely incarcerated or strangulated inguinal hernias require urgent surgical evaluation. Most literature on inguinal hernia management focuses on elective repairs. We aimed to provide evidence-based guidelines for managing inguinal hernias requiring urgent surgical intervention.

methodsAn evidence-based systematic review was performed. Clinically relevant questions regarding defined Population(s), Intervention(s), Comparison(s), and Outcome(s) were selected. These questions centered around the timing of intervention, the use of mesh, the surgical approach, and the use of antibiotics in patients who presented with incarcerated or strangulated inguinal hernias requiring urgent surgical interventions. A comprehensive literature search was completed from 1946 through March 11, 2024. The Grading of Recommendations Assessment, Development and Evaluation methodology was used in the creation of the recommendations. Consensus was achieved for all final recommendations.

resultsOf 7,038 articles reviewed, 34 met the inclusion criteria. Early intervention (<6 hours from symptom onset) was associated with a lower incidence of bowel resection (odds ratio [OR], 0.1 [0.05, 0.29]; p < 0.0001). Hernia repair with mesh was associated with decreased incidence of recurrence (OR, 0.34 [0.13, 0.87]; p = 0.02) and mixed results for surgical site infections. Laparoscopic repairs decreased recurrence rates (OR, 0.75 [0.58, 0.99]; p = 0.03) and had shorter hospital length of stay (mean difference, -3.00 [-5.54, -0.47]; p < 0.01) compared with open repairs. There were not enough studies to address the routine use of postoperative antibiotics. Quality was deemed very low with much of the literature being retrospective studies.

conclusionWe conditionally recommend early surgical intervention for adult patients presenting with acutely incarcerated or strangulated inguinal hernias who are deemed to require surgery. We conditionally recommend mesh repairs over primary tissue repairs and laparoscopic approaches over open approaches for this population. No recommendations can be made regarding the routine use of antibiotics. LEVEL OF EVIDENCE: Systematic Review/Meta-analysis; Level III.

Indexed as

Hernia, InguinalHerniorrhaphyAnti-Bacterial AgentsHumansPractice Guidelines as TopicSurgical MeshTime-to-TreatmentAnti-Bacterial Agentsacute care surgeryInguinal herniameta-analysis

Identifiers

PMID40671180
PMCPMC13585185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.