Evidence map›Paper›PMID 40671119›Full record

ArticleBiology direct2025

Extracellular vesicle-enriched secretome of adipose-derived stem cells upregulates clusterin to alleviate doxorubicin-induced apoptosis in cardiomyocytes.

Wan-Tseng Hsu, Shinji Kobuchi, Tung-Chun Russell Chien, I-Chun Chen, Shohei Hamada, Masayuki Tsujimoto, I-Lin Tsai, Yun-Sheng Wong, Kuan-Hsuan Tung, Ying-Zhen He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology direct, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wan-Tseng HsuSchool of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen S. Rd., R201, Zhongzheng Dist, Taipei, 100025, Taiwan. wantsenghsu@ntu.edu.tw.
Shinji KobuchiLaboratory of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan.
Tung-Chun Russell ChienGraduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
I-Chun ChenDepartment of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan.
Shohei HamadaDivision of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan.
Masayuki TsujimotoLaboratory of Clinical Pharmacy, Kyoto Pharmaceutical University, Kyoto, Japan.
I-Lin TsaiDepartment of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Yun-Sheng WongSchool of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen S. Rd., R201, Zhongzheng Dist, Taipei, 100025, Taiwan.
Kuan-Hsuan TungSchool of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen S. Rd., R201, Zhongzheng Dist, Taipei, 100025, Taiwan.
Ying-Zhen HeSchool of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen S. Rd., R201, Zhongzheng Dist, Taipei, 100025, Taiwan.

Funding

Kyoto Pharmaceutical University 20S01National Science and Technology Council 111-2320-B-002-042-MY2
6 · The paper itself

Abstract

Doxorubicin (DOX) is a potent chemotherapeutic widely used against various cancers, but its clinical application is limited by DOX-induced cardiotoxicity (DIC). This study explored the cardioprotective potential of extracellular vesicle-enriched secretome derived from adipose stem cells (EVS

Indexed as

ApoptosisClusterinDoxorubicinExtracellular VesiclesMyocytes, CardiacSecretomeStem CellsAdipose TissueAnimalsAntibiotics, AntineoplasticCardiotoxicityMiceUp-RegulationAntibiotics, AntineoplasticClusterinDoxorubicin

Identifiers

PMID40671119
PMCPMC12265340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.