ReviewFluids and barriers of the CNS2025
Apocrine secretion by the choroid plexus.
Review in Fluids and barriers of the CNS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The choroid plexus- cerebrospinal fluid axis as a lifespan regulator of neural stem cells and circuit plasticity.Frontiers in neural circuits · 2026Review
- Idiopathic Intracranial Hypertension Animal Models and Venous Sinus Stenting: Status of Disease and Device-Focused Evidence.Brain sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The choroid plexus (ChP) epithelium secretes cerebrospinal fluid (CSF) and signaling factors that influence brain development. In addition to classical secretory pathways, the ChP also employs apocrine secretion, in which large cytoplasmic portions bud from the apical surface in structures called aposomes. Although historically underappreciated, recent imaging and molecular studies demonstrate that this process is calcium-dependent and regulated by neuromodulators such as serotonin. Apocrine secretion contributes distinct cytoplasmic cargo-proteins, organelles, and signaling molecules-to the CSF, with evidence for developmental roles in neurogenesis and progenitor cell differentiation. This review synthesizes structural, functional, and proteomic data supporting ChP apocrine secretion, compares it to other epithelial release mechanisms, and highlights outstanding questions about its regulation and physiological roles. By focusing on this unconventional and understudied mode of secretion, we provide a framework for understanding how ChP-mediated cargo release shapes the CSF environment and contributes to brain development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.