Evidence map›Paper›PMID 40671100›Full record

ArticleCell communication and signaling : CCS2025

Campylobacter jejuni regulates cell cycle progression to potentiate host cell invasion.

Prabhat K Talukdar, Megan C Dines, Eric A Shelden, Brandon A Toy, Amruta Suresh Kale, Ryan R Driskell, Lisa M Gloss, Michael E Konkel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Prabhat K Talukdar *School of Molecular Biosciences, College of Veterinary Sciences, Washington State University, Pullman, WA, 99164, USA.
Megan C Dines *School of Molecular Biosciences, College of Veterinary Sciences, Washington State University, Pullman, WA, 99164, USA.
Eric A SheldenSchool of Molecular Biosciences, College of Veterinary Sciences, Washington State University, Pullman, WA, 99164, USA.
Brandon A ToySchool of Molecular Biosciences, College of Veterinary Sciences, Washington State University, Pullman, WA, 99164, USA.
Amruta Suresh KaleVeterinary Information Systems, College of Veterinary Sciences, Washington State University, Pullman, WA, 99164, USA.
Ryan R DriskellSchool of Molecular Biosciences, College of Veterinary Sciences, Washington State University, Pullman, WA, 99164, USA.
Lisa M GlossSchool of Molecular Biosciences, College of Veterinary Sciences, Washington State University, Pullman, WA, 99164, USA.
Michael E KonkelSchool of Molecular Biosciences, College of Veterinary Sciences, Washington State University, Pullman, WA, 99164, USA. konkel@wsu.edu.

Funding

National Institute of Food and Agriculture 7007860
6 · The paper itself

Abstract

backgroundCampylobacter jejuni is associated with enteritis in humans and domestic animals. Acute C. jejuni-mediated enteritis requires bacterial invasion of intestinal cells with an ensuing host inflammatory response. Known is that C. jejuni invasion of human epithelial cells is dependent on host cell-focal adhesion components, which link the extracellular matrix to the actin cytoskeleton of a cell. Based on the observation that C. jejuni cell invasion engages many of the same components involved in regulating the cell cycle, we hypothesized that C. jejuni regulates the host cell cycle.

methodsFlow cytometry was used to detect the cell cycle phases (G

resultsINT 407 cells infected with C. jejuni showed a slower rate of cell cycle progression and a greater percentage of cells in the G

conclusionsBased on the data, we propose that acute C. jejuni-mediated enteritis (campylobacteriosis) alters the cell cycle phase of enterocytes, cytokine production, and immune cell recruitment, disrupting the intestinal permeability barrier.

Indexed as

Campylobacter InfectionsCampylobacter jejuniCell CycleHost-Pathogen InteractionsCell LineEpithelial CellsHumansInterleukin-8Interleukin-8Cell cycleCell invasionInflammatory responseOxidative stressscRNA-seq

Identifiers

PMID40671100
PMCPMC12269301

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.