ArticleBMC research notes2025
Carbohydrate consumption and cirrhosis-related mortality: a prospective cohort study.
Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver cirrhosis is a chronic liver disease that is often associated with poor prognosis. An important part of the treatment of patients with cirrhosis is related to nutrition. Although carbohydrates constitute the main component of the diet, limited data is available regarding the association of carbohydrate intake with cirrhosis. This study aimed to investigate the relationship between different types of carbohydrates and the risk of mortality in patients with cirrhosis.
methodsThe current study was conducted as a prospective cohort with a follow-up length of 4 years, on 166 newly diagnosed outpatient cirrhosis patients. Evaluation of dietary intake was conducted using a valid 168-item food frequency questionnaire. Carbohydrate intake was classified into total, sugar, glucose, galactose, fructose, sucrose, lactose and maltose. Cox proportional hazards regression models were used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).
resultsThe comparison of dietary intakes indicated a higher intake of calories and protein and a lower intake of fat and carbohydrates in the survivors. After fully adjustment for confounders, significant associations were observed between different types of carbohydrates and cirrhosis-related mortality: sugar (HR = 4.9, CI 95%: 1.5-11.2, P = 0.014), glucose (HR = 3.4, CI 95%: 1.2-10, P = 0.030), fructose (HR = 1.6, CI 95%: 1.02-3, P = 0.043), sucrose (HR = 2.2, CI 95%: 1.2-4, P = 0.024) and lactose (HR = 0.65, CI 95%: 0.3-0.92, P = 0.044). No significant association was found for galactose and maltose.
conclusionMortality in cirrhosis is positively associated with total dietary intake of carbohydrates in addition to sugar, glucose, fructose, sucrose, and negatively associated with dietary intake of lactose. A low carbohydrate diet may help the prognosis of cirrhotic patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.