ArticleBMC women's health2025
Different interventions for OHVIRA/Herlyn-Werner-Wunderlich syndrome based on age and symptoms: a single-institution cohort study.
Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Herlyn-Werner-Wunderlich syndrome in an adolescent with epilepsy: Diagnostic and surgical challenges-first case report from Palestine.Radiology case reports · 2026Article
- Case Report: Soft endoscopic treatment of Herlyn-Werner-Wunderlich syndrome: an innovative clinical procedure for hymen preservation.Frontiers in medicine · 2026Article
- Obstructed Hemivagina, Uterine Didelphys, and Ipsilateral Renal Agenesis: A Case Report of OHVIRA Syndrome.Acta medica Lituanica · 2025Article
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7 authors.
Funding
Abstract
backgroundThis study aimed to describe the clinical characteristics of patients with obstructed hemivagina and ipsilateral renal anomaly (OHVIRA)/Herlyn-Werner-Wunderlich (HWW) syndrome and to evaluate the efficacy of minimally invasive management strategies.
methodsThis cohort study involved a retrospective review of the medical records of patients diagnosed with OHVIRA/ HWW syndrome. Data on chief complaints, diagnostic findings, associated complications, anatomical variations, and therapeutic interventions were extracted.
resultsA total of nine cases were eventually included. The mean age of symptom onset was 23.1 years, whereas the mean age at diagnosis was 20.3 years. Six patients (67%) were diagnosed with OHVIRA syndrome, and an equal proportion (67%) had left-sided abnormalities. Therapeutic interventions were performed in five cases (56%). Statistically, diagnosis after menarche and severe dysmenorrhea was positively correlated with therapeutic interventions (p = 0.048 and p = 0.040, respectively). In one case, symptoms appeared after amenorrhea due to pregnancy, leading to a first-time diagnosis of HWW syndrome in the patient. Management strategies included traditional transvaginal surgery in three patients, vaginoscopic surgery in one patient, and hormone therapy without surgical intervention in another.
conclusionsEarly diagnosis before menarche reduces the risk of therapeutic intervention, while severe dysmenorrhea is a risk factor for therapeutic interventions. Amenorrhea due to pregnancy can result in the re-closure of a pre-existing communicating tract. Minimally invasive management approaches, such as hormone therapy without surgery or vaginoscopic incision, can be effective.
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