Evidence map›Paper›PMID 40671060›Full record

ArticleDiabetology & metabolic syndrome2025

Association between stress hyperglycemia ratio and diabetic retinopathy progression and surgical prognosis: insights from NHANES 2005-2018 and clinical cohort study.

Zetong Nie, Wenjia Xing, Xiang Zhang, Xiaorong Li, Wenbo Li, Bojie Hu

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05631054 (Establishment and Validation of a Risk Prediction Model for Long-term Low Vision After Vitrectomy in Proliferative Diabetic Retinopathy Patients), which is not on this map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05631054 unknown statusnot on this map

Establishment and Validation of a Risk Prediction Model for Long-term Low Vision After Vitrectomy in Proliferative Diabetic Retinopathy Patients

TypeobservationalSponsorTianjin Medical University Eye HospitalRan2022 to 2023Enrolled250ConditionsProliferative Diabetic Retinopathy, Pars Plana Vitrectomy, Risk Prediction Model
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zetong Nie *Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute, School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Wenjia Xing *Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute, School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Xiang ZhangTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute, School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Xiaorong LiTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute, School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Wenbo LiTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute, School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China. wli07@tmu.edu.cn.ORCID http://orcid.org/0009-0002-9948-0288
Bojie HuKey Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital &Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China. bhu07@tmu.edu.cn.ORCID http://orcid.org/0000-0001-7840-8290

Funding

The Science&Technology Development Fund of Tianjin Education Commission for Higher Education 2022ZD058Tianjin Binhai New Area Health Commission Project 2023BWKZ006Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-037A
6 · The paper itself

Abstract

backgroundDiabetic retinopathy (DR), a leading cause of vision loss in working-age adults, is strongly influenced by glycemic control. The stress hyperglycemia ratio (SHR), derived from admission glucose and HbA1c, has emerged as a potential predictor of adverse outcomes, yet its link to DR remains unclear. This study aimed to explore the association between SHR and DR using the NHANES database, as well as its impact on recurrent vitreous hemorrhage (RVH) and neovascular glaucoma (NVG) following pars plana vitrectomy (PPV) in patients with proliferative diabetic retinopathy (PDR).

methodsFirst, the association between SHR and DR was evaluated using multivariable logistic regression analysis based on NHANES database (2005-2018), including 4539 eligible diabetic patients, of whom 968 had DR. Second, 250 eyes from 201 PDR patients undergoing PPV were retrospectively analyzed and divided into two groups by median preoperative SHR. Risk factors for complications were identified using multivariable logistic regression, and paired analyses compared SHR levels at complication onset versus initial PPV surgery.

resultsIn the cross-sectional study based on the NHANES database, multivariate logistic regression revealed a significant positive association between SHR and DR risk after adjusting for all covariates (corrected OR = 1.65, 95% CI: 1.12-2.44; p = 0.014). In the retrospective cohort study, multivariable regression indicated that older age and higher fibrinogen levels were linked to increased postoperative complication risk (p < 0.01). Paired analyses demonstrated significantly higher SHR levels at complication onset compared to initial PPV surgery (p < 0.001).

conclusionSHR was significantly and positively correlated with the incidence of DR. Furthermore, in individuals with PDR, elevation of SHR was closely associated with the occurrence of postoperative complications, suggesting that SHR may be a valuable marker for postoperative adverse events. These results indicate that SHR provides a new clinical basis for the early warning of DR and risk assessment of postoperative complications.

trial registrationClinicaltrials.gov NCT05631054 Registered November 30, 2022 https//clinicaltrials.gov/study/NCT05631054.

Indexed as

Diabetic retinopathyNeovascular glaucomaNHANESPars plana vitrectomyProliferative diabetic retinopathyRecurrent vitreous hemorrhageStress hyperglycemia ratio

Identifiers

PMID40671060
PMCPMC12269122

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.