ArticleBMC biology2025
Marsupial Ig genomics revisited and the potential role of retroelements in the limited number of heavy chain isotypes.
Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Adaptive Immunity in Marsupials.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundMarsupials have limited germline antibody heavy chain variable (VH) gene diversity and more complex light chain variable gene diversity. They also appear to have a limited repertoire of immunoglobulin heavy chain (IgH) isotypes. Using updated genome assemblies, we reannotated and compared the IgH loci of six marsupial species. While the number of VH are limited, there is evidence of greater retention of ancestral VH diversity than previously recognized. Most mammalian lineages have multiple IgH subclasses; for example, mice have four IgG and rabbits have 15 IgA.
resultsMarsupials are unusually uniform in having only a single IgM, IgG, IgE, and IgA and no IgD. This appears to be a marsupial specific limit on heavy chain isotypes, not the ancestral mammalian state. Given the role retroelements have played in chromosomal stability, we investigated their presence in the marsupial IgH, Igκ, and Igλ loci. We found a higher proportion of LINE type retroelements in the region of the opossum IgH locus encoding the constant regions compared to the VH region, and when compared to the mouse IgH locus.
conclusionThese results are consistent with a possible correlation with retroelements playing a potential role in the limited complexity of marsupial IgH isotypes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.