ArticleBMC oral health2025
Protocol for low-level laser therapy (LLLT) to control post-endodontic treatment pain in patients with apical periodontitis: a randomized controlled trial.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundPain after endodontic therapy affects from 2.5 to 60% of patients and may significantly impacts patient's quality of life and adherence to dental treatment. This blind clinical trial protocol was designed to evaluate the analgesic effect of low-level laser therapy (LLLT) and its impact on post-operative pain and on quality of life (QoL) in patients with apical periodontitis (AP) submitted to root canal treatment (RCT).
methods116 patients will be selected. RCT will be performed using the ProTaper Next system. Patients will be randomly allocated into 2 groups: control (naproxen prescription) and test (LLLT). Post-operative pain levels will be assessed through numeric raking scale (NRS) before intervention and at 6 h, 12 h, 24 h and 72 h after endodontic procedures. Quality of life will be assessed using the OHIP-14 before intervention, post-preparation, post-obturation and 6 months after RCT. Descriptive statistics and normality tests will be carried out, and comparison between groups will be estimated for each outcome (post-operative pain and QoL) using parametric or non-parametric tests. The significance level will be set to 5%. DISCUSSION: This study has the potential to strengthen the evidence on postoperative pain management in Endodontics by exploring efficient and safer protocols. Additionally, it may improve the QoL of patients affected by AP.
trial registrationClinicaltrials.gov registration: RBR-5hgcgy4, registered on 31/07/2023, https://ensaiosclinicos.gov.br/rg/RBR-5hgcgy4 . Ethics Reference No: 22706919.0.0000.5336. Trial Sponsor: Pontifical Catholic University of Rio Grande do Sul. The Trial was prospectively registered.
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