Trial reportBMC pulmonary medicine2025
Microbiosthma: a prospective study following respiratory microbiota in young children with severe preschool wheezing to better understand their respiratory future.
Trial report in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06044051 (Dynamique Des Microbiomes Respiratoires Des Voies supérieures et inférieures associée à l'Asthme sévère Des Nourrissons), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dynamique Des Microbiomes Respiratoires Des Voies supérieures et inférieures associée à l'Asthme sévère Des Nourrissons
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preschool wheeze is a frequent infant disease, which can be severe. A continuous infection/inflammation loop at the heart of the pathophysiology is described, which could lead to a dysbiosis. In this context, the main objective of the "Microbiosthma" project is to assess whether dysbiosis of the upper and lower respiratory microbiomes could constitute a physiopathological biomarker of severe preschool wheeze in young children. This project will be divided into three parts: (i) determine the basal composition of the respiratory microbiomes (ii) monitor these microbiomes longitudinally over the course of the severe preschool wheeze, with a one-year follow-up, and (iii) assess the role of immune cell activation and inflammation in the pathogenesis of severe preschool wheeze. The "Microbiosthma" project is a bicentric, prospective study. Bronchial fibroscopy is performed on children aged < 24 months with severe preschool wheeze. One hundred infant nasopharyngeal, bronchoalveolar lavage and sputum samples will be collected over 2 years, and patients will be followed for 12 months. This collection started in September 2023. Microbiome analyses will use a metatranscriptomic approach and immunological analyses for all samples collected. For immunological analysis, key inflammatory cytokines in bronchoalveolar lavage samples will be measured. Host sequencing data obtained by NGS sequencing will be analysed for transcriptomic signatures of inflammatory profiles. The aim of the "Microbiosthma" project is to understand the respiratory microbiome of the physiopathological process involved in the development of severe preschool wheeze. This original project will therefore identify the nature of potential dysbiosis, the relationship between different respiratory microbiomes and the potential role of the immune system in this pathogenesis. The registration number is NCT06044051 (CCP Nord-Ouest, 07/11/2023).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.