ArticleBMC oral health2025
Vitamins C and E alleviate the deleterious effects of electronic cigarettes on tongue muscles and nerves in rat model.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Aging-Induced Downregulation of DNA Polymerase β Impairing Base Excision Repair Causes Testicular Dysfunction.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study evaluated the ultrastructural effects of electronic cigarettes' (EC) exposure in rat lingual nerves and muscles and assessed the therapeutic roles of vitamins C, E, and their combination.
methodsForty adult male albino rats were allocated into 5 groups. CONTROL: injected saline intraperitoneally, EC group: injected EC-liquid containing nicotine at a dose of 0.75 mg/kg, EC + C group: injected with EC-liquid and then supplemented orally with vitamin C, EC + C group injected with EC-liquid and then supplemented orally with vitamin E, and EC + C&E group: injected with EC-liquid and then supplemented orally with a combination of both vitamins. Transmission electron microscopy (TEM) and oxidative stress biomarkers malondialdehyde (MDA), and superoxide dismutase (SOD) were used to assess tissue damage and antioxidant effects.
resultsEC group showed disrupted myelin sheaths, abnormal mitochondria, elevated MDA, and reduced SOD activity, indicating oxidative damage. EC + C group showed muscular recovery but did not significantly improve oxidative markers (p > 0.05) when compared to EC group. EC + E and EC + C&E groups showed regular myelin sheaths, normal mitochondria, and significant improvements in MDA and SOD levels compared to the EC group (p < 0.01).
conclusionsVitamin E alone or combined with vitamin C effectively mitigates EC-induced oxidative stress and ultrastructural damage in muscular and nerve tissues. Vitamin C alone offers insufficient protection, mostly supporting muscular recovery without significantly improving nerve integrity or oxidative status.
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