ArticleInfectious diseases and therapy2025
Impact of Revised Vaccination Recommendations for Mature Infants on Premature Infants' Vaccination Compliance in Germany.
Article in Infectious diseases and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe German Standing Committee on Vaccination (STIKO) changed the vaccination schedule for mature infants from a 3 + 1 to a 2 + 1 schedule for pneumococcal conjugate vaccines (PCV) in August 2015 and for hexavalent vaccines (HEXA) in August 2020. A 3 + 1 schedule is still recommended for premature infants for both vaccinations. This study analyzed the impact of the changed recommendations of PCV and HEXA vaccination on the vaccination compliance and adherence of premature infants.
methodsA retrospective claims data analysis was conducted using the InGef Research Database. The study population included all premature and mature infants born in 2013, 2016, 2018, and 2020 with an individual follow-up of 24 months. Premature infants were identified by ICD-10-GM codes P07.2 and P07.3. Documented records of vaccinations were assessed in the outpatient setting. Full vaccination rates of PCV and HEXA vaccination according to STIKO recommendations, valid in the respective observational year and maturity of birth, were analyzed.
resultsAfter the change in STIKO recommendations in 2020, the full HEXA vaccination rate for premature infants decreased significantly to 57.8% (2018, 71.0%), while it increased to 81.3% (2018, 73.8%) for mature infants. A similar pattern was observed during the transition from a 3 + 1 to a 2 + 1 PCV vaccination schedule among mature infants comparing birth cohorts 2013 (premature 65.4% vs mature 68.3%) and 2016 (premature 40.8% vs mature 75.6%).
conclusionDespite the continued recommendation for a 3 + 1 PCV and HEXA vaccination schedule in premature infants, a significant decrease of completed immunization was observed for both vaccines following the adjusted recommendations for mature infants. These findings underscore the need for enhanced efforts to promote adherence to STIKO guidelines to safeguard this vulnerable population of premature infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.