ArticleAnalytical and bioanalytical chemistry2025
Development and validation of a non-chromatographic method for mercury and methylmercury in finfish using thermal decomposition gold amalgamation atomic absorption spectrophotometry (TDA-AAS) and salting-out assisted liquid-liquid extraction (SALLE).
Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Accurate technologies and methods are needed to monitor both total and methylmercury in the marine food supply. Thermal decomposition gold amalgamation atomic absorption spectrophotometry (TDA-AAS) is an efficient and cost-effective technique for measuring low levels of total mercury requiring no sample preparation. Measuring methylmercury with TDA-AAS requires isolating methylmercury from the matrix and other mercury species prior to detection. We developed a method that uses ethyl acetate instead of a legacy non-polar solvent, toluene. Toluene is a potentially hazardous and problematic solvent whereas ethyl acetate is greener and safer. Additionally, the salting-out assisted liquid-liquid extraction (SALLE) approach with ethyl acetate avoids emulsion formation throughout extraction. We describe method development and validation of a SALLE and TDA-AAS detection for methylmercury in finfish. From 10 reference materials, our method recovered 80-118% of total or methylmercury with Z scores ranging from -1.98 to 2.75 (n = 184). The LOD and LOQ of the method for methylmercury were 3.8 and 27 ng/g, respectively. From extraction to detection, accurate results were obtained from a sample in less than 2 h for both total mercury and methylmercury.
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