ArticleNature2025
Neutrophils drive vascular occlusion, tumour necrosis and metastasis.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Neutrophil-driven immunosuppression in cancer.Cell insight · 2026Review
- DVT-primed neutrophils reshape the brain microenvironment to promote brain metastasis.bioRxiv : the preprint server for biology · 2026Article
- Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Neutrophils in cancer.Nature reviews. Cancer · 2026Review
- α-KG conformationally stabilizes nuclear GLUD1-SNAIL complex to fuel trans-endothelial migration in metastasis.Nature communications · 2026Article
- Epithelial-mesenchymal transition in carcinoma: navigating phenotypic states to target resistance and metastasis.Cancer metastasis reviews · 2026Review
- Neutrophil extracellular traps promote liver metastasis by impairing NK cell-dependent tumor surveillance via CCDC25.Nature communications · 2026Article
- P2RY13-Negative Tumor-Associated Macrophages Promote NETosis and Are Associated with Poor Prognosis Across Multiple Cancers.Cancers · 2026Article
- Neutrophil-based immunotherapy: A metabolic lens on mechanisms and therapeutic implications.Clinical and translational medicine · 2026Review
- FGL2-HDAC11 Drives Immunothrombosis via NETs-Mediated Endothelial Capillarization in MASLD Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tumor-platelet cross talk in cancer: mechanisms, thrombotic risk, and translational opportunities.Blood advances · 2026Review
- Cellular architecture and neighborhood-informed virtual spatial tumor profiling from histopathology.Cell · 2026Article
- Roles of neutrophil extracellular traps in cancer immunotherapy resistance and therapeutic targeting.Biomarker research · 2026Review
- Epithelial-mesenchymal transition and immunosuppression: Two sides of the same coin.Cellular and molecular life sciences : CMLS · 2026Review
- Podoplanin-defined tumour plasticity and CCR7-mediated lymphatic metastasis in triple-negative breast cancer.British journal of cancer · 2026Article
- Neutrophil extracellular traps: A central player in liver diseases.Hepatology communications · 2026Review
- Iron overload in the tumor microenvironment induces CD8Nature communications · 2026Article
- The vascular niche: an orchestrator of the spatiotemporal dynamics of distant metastasis.Acta pharmacologica Sinica · 2026Review
- Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neutrophil Elastase as a Prognostic Biomarker and Driver of Tumor Progression in Diffuse Large B-Cell Lymphoma.Cancer medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Jose M AdroverCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. jose.adrover@crick.ac.uk.ORCID 0000-0002-1395-5477
Xiao HanCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0002-4036-8710
Lijuan SunCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Takeo FujiiCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0003-3747-2688
Nicole SivetzCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Juliane Daßler-PlenkerCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Clary EvansCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Jessica PetersNorthwell Health Cancer Institute, Lake Success, NY, USA.
Xue-Yan HeCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0001-5423-5997
Courtney D CannonDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Won Jin HoDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2644-5086
George RaptisNorthwell Health Cancer Institute, Lake Success, NY, USA.
R Scott PowersGraduate Program in Genetics, Stony Brook University, Stony Brook, NY, USA.
Mikala EgebladCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. mikala.egeblad@jhmi.edu.ORCID 0000-0002-3371-1445
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6MSingle-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI David A Tuveson · 1987 to 2026
$118.9MIdentifying the pro-metastatic mechanisms of neutrophil extracellular trapsR01CA237413 · NCI · JOHNS HOPKINS UNIVERSITY · PI EGEBLAD, MIKALA · 2020 to 2024
$2.6MDefining brain-body feedback loops mediating stress-induced metastasisU01CA293470 · NCI · JOHNS HOPKINS UNIVERSITY · PI Mikala Egeblad, Linda Van Aelst · 2024 to 2026
$2.0MDetermining the role of neutrophils in anti-tumor immunity and immune-related adverse events in the context of T cell-based therapiesR01CA297338 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Mikala Egeblad, Taha Merghoub · 2025 to 2026
$1.4MMass Cytometer CyTOF XT for Single-Cell BiologyS10OD034407 · OD · JOHNS HOPKINS UNIVERSITY · PI HO, WON JIN · 2024 to 2024
$499kImmune Regulation of Dormancy at the Metastatic SiteF99CA284292 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI HAN, XIAO · 2023 to 2025
$101kThe impact of sepsis-induced inflammation on pancreatic cancer liver metastasisF31CA281246 · NCI · COLD SPRING HARBOR LABORATORY · PI SIVETZ, NICOLE · 2023 to 2024
$93kNCI NIH HHS F31 CA281246NCI NIH HHS F99 CA284292NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA045508NCI NIH HHS R01 CA237413NCI NIH HHS R01 CA297338NCI NIH HHS U01 CA293470NIH HHS S10 OD034407Wellcome Trust FC001003
Abstract
Tumour necrosis is associated with poor prognosis in cancer
Indexed as
NecrosisNeoplasm MetastasisNeoplasmsNeovascularization, PathologicNeutrophilsAnimalsCell Line, TumorEpithelial-Mesenchymal TransitionExtracellular TrapsFemaleHumansLung NeoplasmsMaleMiceMice, Inbred C57BL
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.